公开(公告)号：US12090189B2

公开(公告)日：2024-09-17

申请号：US18474456

申请日：2023-09-26

Applicant: University of Florida Research Foundation, Inc.

Inventor： Daiqing Liao ,  Iqbal Mahmud ,  Guimei Tian

IPC: A61K38/04 ,  A61K47/10 ,  A61K47/36 ,  A61P35/00 ,  A61K45/06

CPC classification number: A61K38/04 ,  A61K47/10 ,  A61K47/36 ,  A61P35/00 ,  A61K45/06

Abstract: Disclosed herein is a method for treating cancer in a subject that involves administering to the subject a therapeutically effective amount of a composition comprising a polypeptide that comprises an amino acid sequence corresponding to at the C-terminal SUMO-interacting motif (SIM2) of a DAXX protein. The disclosed polypeptide is not a functional DAXX protein but competes with endogenous DAXX for binding to SUMO.

公开(公告)号：US20240066094A1

公开(公告)日：2024-02-29

申请号：US18474456

申请日：2023-09-26

Applicant: University of Florida Research Foundation, Inc.

Inventor： Daiqing Liao ,  Iqbal Mahmud ,  Guimei Tian

IPC: A61K38/04 ,  A61K47/10 ,  A61K47/36 ,  A61P35/00

CPC classification number: A61K38/04 ,  A61K47/10 ,  A61K47/36 ,  A61P35/00 ,  A61K45/06

Abstract: Disclosed herein is a method for treating cancer in a subject that involves administering to the subject a therapeutically effective amount of a composition comprising a polypeptide that comprises an amino acid sequence corresponding to at the C-terminal SUMO-interacting motif (SIM2) of a DAXX protein. The disclosed polypeptide is not a functional DAXX protein but competes with endogenous DAXX for binding to SUMO.

公开(公告)号：US20210113649A1

公开(公告)日：2021-04-22

申请号：US17044547

申请日：2019-04-05

Applicant: University of Florida Research Foundation, Inc.

Inventor： Daiqing Liao ,  Iqbal Mahmud ,  Guimei Tian

IPC: A61K38/04 ,  A61P35/00 ,  A61K47/10 ,  A61K47/36

Abstract: Disclosed herein is a method for treating cancer in a subject that involves administering to the subject a therapeutically effective amount of a composition comprising a polypeptide that comprises an amino acid sequence corresponding to at the C-terminal SUMO-interacting motif (SIM2) of a DAXX protein. The disclosed polypeptide is not a functional DAXX protein but competes with endogenous DAXX for binding to SUMO.