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公开(公告)号:US12090189B2
公开(公告)日:2024-09-17
申请号:US18474456
申请日:2023-09-26
Inventor: Daiqing Liao , Iqbal Mahmud , Guimei Tian
Abstract: Disclosed herein is a method for treating cancer in a subject that involves administering to the subject a therapeutically effective amount of a composition comprising a polypeptide that comprises an amino acid sequence corresponding to at the C-terminal SUMO-interacting motif (SIM2) of a DAXX protein. The disclosed polypeptide is not a functional DAXX protein but competes with endogenous DAXX for binding to SUMO.
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公开(公告)号:US20240066094A1
公开(公告)日:2024-02-29
申请号:US18474456
申请日:2023-09-26
Inventor: Daiqing Liao , Iqbal Mahmud , Guimei Tian
Abstract: Disclosed herein is a method for treating cancer in a subject that involves administering to the subject a therapeutically effective amount of a composition comprising a polypeptide that comprises an amino acid sequence corresponding to at the C-terminal SUMO-interacting motif (SIM2) of a DAXX protein. The disclosed polypeptide is not a functional DAXX protein but competes with endogenous DAXX for binding to SUMO.
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公开(公告)号:US20210113649A1
公开(公告)日:2021-04-22
申请号:US17044547
申请日:2019-04-05
Inventor: Daiqing Liao , Iqbal Mahmud , Guimei Tian
Abstract: Disclosed herein is a method for treating cancer in a subject that involves administering to the subject a therapeutically effective amount of a composition comprising a polypeptide that comprises an amino acid sequence corresponding to at the C-terminal SUMO-interacting motif (SIM2) of a DAXX protein. The disclosed polypeptide is not a functional DAXX protein but competes with endogenous DAXX for binding to SUMO.
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