公开(公告)号：US20220134694A1

公开(公告)日：2022-05-05

申请号：US17647859

申请日：2022-01-13

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: B29D11/00 ,  G02C7/04

Abstract: In general, the disclosure relates to methods and compositions for preparing colorants useful for preparing pigmented hydrogels. The disclosure further relates to pigmented hydrogels comprising the disclosed colorants. In some instances, the colorant is an alcohol extract of an agro-material, such as turmeric, paprika, spinach, and/or pokorny woad or the colorants comprise one or more of: a carotenoid, chlorophyll-a, chlorophyll-b, a curcumoid, or indigorubin. Alternatively, the colorant can be carbon black. The disclosure further relates to contact lenses comprising the disclosed pigmented hydrogels.

公开(公告)号：US10786429B2

公开(公告)日：2020-09-29

申请号：US16391588

申请日：2019-04-23

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: A61J1/14 ,  B01D39/16 ,  A61F9/00 ,  A61K9/00 ,  A61K9/08 ,  A61K31/5575 ,  A61K31/573 ,  A61K47/18

Abstract: A BAK removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 μm and the plug has a surface area of 30 mm2 to 2 mm2 and a length of 2 mm to 25 mm and wherein the microparticles of a hydrophilic polymeric gel has a pore radius of 3 to 60 μm.

公开(公告)号：US12156850B2

公开(公告)日：2024-12-03

申请号：US17231233

申请日：2021-04-15

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: A61J1/14 ,  B01J20/26 ,  B01J20/28 ,  A61K9/00 ,  A61K9/08 ,  A61K31/498 ,  A61K31/5377 ,  A61K47/18 ,  B01D15/00

Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of a homopolymer comprising a hydrophilic repeating unit or of a copolymer comprising at least one hydrophilic repeating unit and at least one hydrophobic repeating unit. The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The homopolymers have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

公开(公告)号：US11033457B2

公开(公告)日：2021-06-15

申请号：US16388470

申请日：2019-04-18

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: A61J1/14 ,  B01J20/26 ,  B01J20/28 ,  A61K9/00 ,  A61K9/08 ,  A61K31/498 ,  A61K31/5377 ,  A61K47/18 ,  B01D15/00

Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of a homopolymer comprising a hydrophilic repeating unit or of a copolymer comprising at least one hydrophilic repeating unit and at least one hydrophobic repeating unit. The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The homopolymers have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

公开(公告)号：US11260612B2

公开(公告)日：2022-03-01

申请号：US16690324

申请日：2019-11-21

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: B29D11/00 ,  G02C7/04

Abstract: In general, the disclosure relates to methods and compositions for preparing colorants useful for preparing pigmented hydrogels. The disclosure further relates to pigmented hydrogels comprising the disclosed colorants. In some instances, the colorant is an alcohol extract of an agro-material, such as turmeric, paprika, spinach, and/or woad or the colorants comprise one or more of: a carotenoid, chlorophyll-a, chlorophyll-b, a curcumoid, or indigorubin. Alternatively, the colorant can be carbon black. The disclosure further relates to contact lenses comprising the disclosed pigmented hydrogels.

公开(公告)号：US20210338527A1

公开(公告)日：2021-11-04

申请号：US17231233

申请日：2021-04-15

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: A61J1/14 ,  B01J20/26 ,  B01J20/28

Abstract: A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of a homopolymer comprising a hydrophilic repeating unit or of a copolymer comprising at least one hydrophilic repeating unit and at least one hydrophobic repeating unit. The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The homopolymers have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.

公开(公告)号：US20190247277A1

公开(公告)日：2019-08-15

申请号：US16391588

申请日：2019-04-23

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: A61J1/14 ,  B01D39/16

Abstract: A BAK removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 μm and the plug has a surface area of 30 mm2 to 2 mm2 and a length of 2 mm to 25 mm and wherein the microparticles of a hydrophilic polymeric gel has a pore radius of 3 to 60 μm.

公开(公告)号：US11826974B2

公开(公告)日：2023-11-28

申请号：US17647859

申请日：2022-01-13

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: B29D11/00 ,  G02C7/04

CPC classification number: B29D11/00903 ,  B29D11/00038 ,  G02C7/04

Abstract: In general, the disclosure relates to methods and compositions for preparing colorants useful for preparing pigmented hydrogels. The disclosure further relates to pigmented hydrogels comprising the disclosed colorants. In some instances, the colorant is an alcohol extract of an agro-material, such as turmeric, paprika, spinach, and/or pokorny woad or the colorants comprise one or more of: a carotenoid, chlorophyll-a, chlorophyll-b, a curcumoid, or indigorubin. Alternatively, the colorant can be carbon black. The disclosure further relates to contact lenses comprising the disclosed pigmented hydrogels.

公开(公告)号：US20200156336A1

公开(公告)日：2020-05-21

申请号：US16690324

申请日：2019-11-21

Applicant: University of Florida Research Foundation, Inc.

Inventor： Anuj Chauhan ,  Phillip J. Dixon ,  Poorvajan Sekar

IPC: B29D11/00 ,  G02C7/04

Abstract: In general, the disclosure relates to methods and compositions for preparing colorants useful for preparing pigmented hydrogels. The disclosure further relates to pigmented hydrogels comprising the disclosed colorants. In some instances, the colorant is an alcohol extract of an agro-material, such as turmeric, paprika, spinach, and/or woad or the colorants comprise one or more of: a carotenoid, chlorophyll-a, chlorophyll-b, a curcumoid, or indigorubin. Alternatively, the colorant can be carbon black. The disclosure further relates to contact lenses comprising the disclosed pigmented hydrogels.