公开(公告)号：US20220175887A1

公开(公告)日：2022-06-09

申请号：US17555320

申请日：2021-12-17

申请人： University of Florida Research Foundation, Incorporated

发明人： Jeffrey S. Bartlett ,  Steven C. Ghivizzani

IPC分类号： A61K38/20 ,  A61K9/00 ,  A61K35/32 ,  A61K35/761

摘要： Methods and compositions for treating symptoms of conditions such as but not limited to osteoarthritis and rheumatoid arthritis. The methods may feature direct intraarticular injection of a recombinant self-complementary adeno-associated virus (sc-rAAV) with a vector adapted to express a modified IL-1Ra peptide. The methods of the present invention may express a therapeutically effective amount of the modified IL-1Ra peptide so as to ameliorating symptoms associated with the condition being treated.

公开(公告)号：US11207382B2

公开(公告)日：2021-12-28

申请号：US16326488

申请日：2017-08-18

申请人： University of Florida Research Foundation, Incorporated

发明人： Steven C. Ghivizzani

IPC分类号： A61K38/20 ,  A61K35/761 ,  A61K9/00 ,  A61K35/32 ,  A61K45/06

摘要： Methods and compositions for treating symptoms of conditions such as but not limited to osteoarthritis and rheumatoid arthritis. The methods may feature direct intraarticular injection of a recombinant self-complementary adeno-associated virus (sc-rAAV) with a vector adapted to express a modified IL-1Ra peptide. The methods of the present invention may express a therapeutically effective amount of the modified IL-1Ra peptide so as to ameliorating symptoms associated with the condition being treated.

公开(公告)号：US20200071371A1

公开(公告)日：2020-03-05

申请号：US16467141

申请日：2017-12-07

申请人： University of Florida Research Foundation, Incorporated

发明人： Steven C. Ghivizzani

IPC分类号： C07K14/47 ,  C12N15/86

摘要： The present disclosure relates to compositions and methods for treatment of degenerative conditions of large weight-bearing joints, such as osteoarthritis, by intra-articular delivery of a codon-modified IL-1Ra encoding gene.

公开(公告)号：US20240327479A1

公开(公告)日：2024-10-03

申请号：US18598468

申请日：2024-03-07

申请人： University of Florida Research Foundation, Incorporated

发明人： Steven C. Ghivizzani

IPC分类号： C07K14/47 ,  A61K9/00 ,  C12N15/86

CPC分类号： C07K14/4703 ,  C12N15/86 ,  A61K9/0019 ,  C12N2750/14143

摘要： The present disclosure relates to compositions and methods for treatment of degenerative conditions of large weight-bearing joints, such as osteoarthritis, by intra-articular delivery of a codon-modified IL-1Ra encoding gene.

公开(公告)号：US11958886B2

公开(公告)日：2024-04-16

申请号：US16467141

申请日：2017-12-07

申请人： University of Florida Research Foundation, Incorporated

发明人： Steven C. Ghivizzani

IPC分类号： C07K14/47 ,  C12N15/86 ,  A61K9/00

CPC分类号： C07K14/4703 ,  C12N15/86 ,  A61K9/0019 ,  C12N2750/14143

摘要： The present disclosure relates to compositions and methods for treatment of degenerative conditions of large weight-bearing joints, such as osteoarthritis, by intra-articular delivery of a codon-modified IL-1Ra encoding gene.