公开(公告)号：US11028041B2

公开(公告)日：2021-06-08

申请号：US16640897

申请日：2018-08-23

Applicant: University of Kansas

Inventor： Brian S. J. Blagg ,  Vincent Matthew Crowley

IPC: C07C69/94 ,  A61P35/04 ,  C07C229/52 ,  C07D213/55 ,  C07D213/643 ,  C07C69/76 ,  A61K31/216 ,  A61K31/44 ,  A61P27/02

Abstract: The present technology provides compounds selective for the Grp94 isoform, as well as compositions including such compounds, that are useful for treatment of multiple myeloma, melanoma, lung cancer, hepatocellular carcinoma, breast cancer, prostate cancer, and/or glaucoma. Methods using the compounds are also provided.

公开(公告)号：US12269798B2

公开(公告)日：2025-04-08

申请号：US17341047

申请日：2021-06-07

Applicant: University of Kansas

Inventor： Brian S. J. Blagg ,  Vincent Matthew Crowley

IPC: C07C69/94 ,  A61K31/216 ,  A61K31/44 ,  A61P27/02 ,  A61P35/04 ,  C07C69/76 ,  C07C69/78 ,  C07C69/88 ,  C07C219/34 ,  C07C229/52 ,  C07D213/55 ,  C07D213/643

Abstract: The present technology provides compounds selective for the Grp94 isoform, as well as compositions including such compounds, that are useful for treatment of multiple myeloma, melanoma, lung cancer, hepatocellular carcinoma, breast cancer, prostate cancer, and/or glaucoma. Methods using the compound are also provided.

公开(公告)号：US20210300872A1

公开(公告)日：2021-09-30

申请号：US17341047

申请日：2021-06-07

Applicant: University of Kansas

Inventor： Brian S.J. Blagg ,  Vincent Matthew Crowley

IPC: C07D213/643 ,  C07C69/78 ,  C07C219/34

Abstract: The present technology provides compounds selective for the Grp94 isoform, as well as compositions including such compounds, that are useful for treatment of multiple myeloma, melanoma, lung cancer, hepatocellular carcinoma, breast cancer, prostate cancer, and/or glaucoma. Methods using the compound are also provided.