公开(公告)号：US20250135033A1

公开(公告)日：2025-05-01

申请号：US18834366

申请日：2023-01-31

Applicant: University of Massachusetts

Inventor： Heather Gray-Edwards ,  Miguel Sena Esteves ,  Jillian Gallagher

IPC: A61K48/00 ,  A61K38/47 ,  A61K38/48 ,  A61P3/00 ,  C12N15/86

Abstract: In some aspects the disclosure provides compositions and methods for promoting expression of functional NEU1 protein in a subject. In other aspects, the disclosure provides compositions and methods for treating sialidosis, galactosialidosis, and/or Alzheimer's Disease in a subject having or suspected of having sialidosis, galactosialidosis, and/or Alzheimer's Disease.