公开(公告)号：US20230348914A1

公开(公告)日：2023-11-02

申请号：US17918689

申请日：2021-04-13

Applicant: University of Massachusetts

Inventor： Jun Xie ,  Yi Wang ,  Sha Zhu ,  Guangping Gao

IPC: C12N15/113 ,  C12N15/86 ,  A61K48/00 ,  A61P1/16

CPC classification number: C12N15/1137 ,  C12N15/86 ,  A61K48/005 ,  A61P1/16

Abstract: Aspects of the disclosure relate to isolated nucleic acids encoding one or more inhibitory nucleic acids. In some embodiments, the inhibitory nucleic acids are microRNAs (miRNAs) or artificial microRNAs (amiRNAs). The inhibitory nucleic acids may target one or more genes involved in cytochrome p450 toxicity, for example Slc16a2, Acls5, and Cyb5b. In some embodiments, an inhibitory nucleic acid is a miR-375. The disclosure relates, in some aspects, to methods of reducing cytochrome p450-related toxicity in a cell (e.g., a liver cell) by administering the isolated nucleic acids of the disclosure.