公开(公告)号：US20230057380A1

公开(公告)日：2023-02-23

申请号：US17779793

申请日：2020-11-25

申请人： University of Massachusetts ,  Chengdu Kanghong Biotechnology Co. Ltd.

发明人： Guangping Gao ,  Phillip Tai ,  Claudio Punzo ,  Zunhong Ke

IPC分类号： C12N7/00 ,  C07K16/22 ,  C12N15/86 ,  A61K9/00

摘要： Aspects of the disclosure relate to a recombinant adeno-virus encoding an anti-Vascular endothelial cell growth factor (VEGF) agent in a cell or subject (e.g., rAAV2.7m8-KH902). In some embodiments, compositions described herein are useful for treating subjects having diseases associated with angiogenesis or aberrant VEGF activity/signaling.