专利检索 ap:("University of Miami" OR "The Board of Trustees of the Leland Stanford Junior University") AND inv:"Jinliang LI" 第 1 页

1.

发明公开
TREATMENT OF HEART DISEASE BY DISRUPTION OF THE ANCHORING OF PP2A 审中-公开

公开(公告)号：US20240165268A1

公开(公告)日：2024-05-23

申请号：US18420397

申请日：2024-01-23

申请人： University of Miami , The Board of Trustees of the Leland Stanford Junior University

发明人： Michael S. KAPILOFF , Jinliang LI

IPC分类号： A61K48/00 , A61K35/761 , A61P9/04

CPC分类号： A61K48/0066 , A61K35/761 , A61P9/04

摘要： The present invention provides a method of treating heart failure with reduced ejection fraction, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the anchoring of PP2A to mAKAPβ. This composition is preferably in the form of a viral based gene therapy vector that encodes a fragment of mAKAPβ to which PP2A binds.

2.

发明申请
TREATMENT OF HEART DISEASE BY DISRUPTION OF THE ANCHORING OF PP2A 有权

公开(公告)号：US20220008560A2

公开(公告)日：2022-01-13

申请号：US16818771

申请日：2020-03-13

申请人： University of Miami , The Board of Trustees of the Leland Stanford Junior University

发明人： Michael KAPILOFF , Jinliang LI

IPC分类号： A61K48/00 , A61K35/761 , A61P9/04

摘要： The present invention provides a method of treating heart failure with reduced ejection fraction, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the anchoring of PP2A to mAKAPβ. This composition is preferably in the form of a viral based gene therapy vector that encodes a fragment of mAKAPβ to which PP2A binds.