公开(公告)号：US09708276B2

公开(公告)日：2017-07-18

申请号：US14351126

申请日：2012-10-10

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Zhou Wang ,  Joel Byron Nelson ,  Minh Mindy Bao Nguyen ,  John S. Lazo ,  Paul A. Johnston ,  Peter Wipf

IPC分类号： A61K31/407 ,  A61K31/496 ,  C07D261/08 ,  C07D295/16 ,  A61K31/495 ,  C07D401/04 ,  C07D235/02 ,  C07D403/04 ,  C07D409/04 ,  C07D413/04 ,  C07D241/04 ,  C07D417/04 ,  C07D261/04 ,  A61K31/4188 ,  A61K31/58 ,  A61K31/4965 ,  A61K45/06 ,  C07D487/04

CPC分类号： A61K31/496 ,  A61K31/407 ,  A61K31/4188 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/58 ,  A61K45/06 ,  C07D235/02 ,  C07D241/04 ,  C07D261/04 ,  C07D261/08 ,  C07D295/16 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/08 ,  C07D487/04 ,  A61K2300/00

摘要： A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: (a) a phenyl-substituted imidazole, or a pharmaceutically acceptable salt or ester thereof; or (b) a compound, or a pharmaceutically acceptable salt or ester thereof, having a formula I of: wherein R20 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; R21 is an alkanediyl or a substituted alkanediyl; a is 0 or 1; c is 0 or 1; X is C or S; R22 is a moiety that includes at least one divalent amino radical; and R23 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group.