公开(公告)号：US20220344059A1

公开(公告)日：2022-10-27

申请号：US17760558

申请日：2020-11-24

申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Robert Clark ,  Christopher Michael Horvat ,  Alicia Ka Win Au ,  Amie Barda

IPC分类号： G16H50/30 ,  G16H10/60 ,  G06N20/00

摘要： Provided herein are systems, methods, and computer program products for use in detecting and responding to patient neuromorbidity. The method includes receiving patient cohort data from an electronic health record system and identifying features of the patient cohort data using a feature selection evaluating parameter. The method also includes training, using the features, a patient classification model configured to classify patients according to neuromorbidity risk. The method further includes receiving a patient dataset associated with a patient and generating, by inputting the patient dataset into the patient classification model, a patient classification of the patient comprising a probability of the patient developing a neuromorbidity over a time period. The method further includes, in response to the probability of the patient developing a neuromorbidity satisfying a predetermined threshold, transmitting an alert to a computing device associated with a physician, a nurse, and/or an advanced practice provider of deteriorating brain health.

公开(公告)号：US20220071501A1

公开(公告)日：2022-03-10

申请号：US17524791

申请日：2021-11-12

申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Robert Clark ,  Gilles Clermont ,  Michael Wolf

IPC分类号： A61B5/03 ,  A61B5/00

摘要： System for monitoring intracranial compliance in a patient includes an intracranial pressure sensor, configured to obtain a measurement indicative of an intracranial pressure of a patient, a CO2 sensor, configured to obtain a measurement indicative of a CO2 level of the patient, and a processor, configured to determine an intracranial compliance from the measurements indicative of the intracranial pressure and the CO2 level. Methods for monitoring intracranial compliance in a patient are also provided.

公开(公告)号：US11090389B2

公开(公告)日：2021-08-17

申请号：US16340237

申请日：2017-10-13

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Hulya Bayir ,  Robert Clark ,  Tanja Krainz ,  Peter Wipf

IPC分类号： A61K47/64 ,  A61K38/00 ,  A61P39/00 ,  A61K31/4184 ,  A61K45/06

摘要： A mitochondrial-targeted PARP inhibitor is provided herein, as well as methods of making and using the mitochondrial-targeted PARP inhibitor.

公开(公告)号：US11759524B2

公开(公告)日：2023-09-19

申请号：US17403182

申请日：2021-08-16

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Hulya Bayir ,  Peter Wipf ,  Tanja Krainz ,  Robert Clark

IPC分类号： A61K47/64 ,  A61P39/00 ,  A61K31/4184 ,  A61K45/06

CPC分类号： A61K47/64 ,  A61K31/4184 ,  A61K45/06 ,  A61P39/00

摘要： A mitochondrial-targeted PARP inhibitor is provided herein, as well as methods of making and using the mitochondrial-targeted PARP inhibitor.

公开(公告)号：US20210379191A1

公开(公告)日：2021-12-09

申请号：US17403182

申请日：2021-08-16

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Hulya Bayir ,  Peter Wipf ,  Tanja Krainz ,  Robert Clark

IPC分类号： A61K47/64 ,  A61P39/00 ,  A61K31/4184 ,  A61K45/06

摘要： A mitochondrial-targeted PARP inhibitor is provided herein, as well as methods of making and using the mitochondrial-targeted PARP inhibitor.

公开(公告)号：US20200038518A1

公开(公告)日：2020-02-06

申请号：US16340237

申请日：2017-10-13

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Hulya Bayir ,  Robert Clark ,  Tanja Krainz ,  Peter Wipf

IPC分类号： A61K47/64 ,  A61K45/06 ,  A61K31/4184 ,  A61P39/00

摘要： A mitochondrial-targeted PARP inhibitor is provided herein, as well as methods of making and using the mitochondrial-targeted PARP inhibitor.