公开(公告)号：US20240374681A1

公开(公告)日：2024-11-14

申请号：US18688651

申请日：2022-09-02

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education

Inventor： Lisa Cencia Rohan ,  Xin Tong ,  Lin Wang

IPC: A61K38/16 ,  A61K9/00 ,  A61K9/19 ,  A61K31/675 ,  A61K47/26

Abstract: Provided herein are stable hypotonic or isotonic formulations containing active ingredients, such as antiviral compositions, or anti-retroviral compositions for intrarectal delivery to provide prophylaxis against viral infections.

公开(公告)号：US20230218715A1

公开(公告)日：2023-07-13

申请号：US17999235

申请日：2021-05-18

Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. ,  UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Kenneth E. Palmer ,  Joshua L. Fuqua ,  Lisa Cencia Rohan ,  Lin Wang ,  Barry R. O'Keefe

IPC: A61K38/16 ,  A61K9/00 ,  A61K47/36 ,  A61P31/14

CPC classification number: A61K38/168 ,  A61K9/0043 ,  A61K47/36 ,  A61P31/14

Abstract: The present invention relates to griffithsin polypeptides and methods of using the same in inhibition of viral infection. Certain embodiments of the present invention relate to modified griffithsin polypeptides and methods of inhibiting coronavirus infection in a host by administering modified griffithsin polypeptides to the upper respiratory tract of the host. Further embodiments relate to an intranasal spray formulation including griffithsin polypeptides in a composition including a preservative and a viscosity modifier.