专利检索 ap:("University of Pittsburgh - Of the Commonwealth System of Higher Education" OR "National Institute of Health, A Component of the U.S Department of Health AND Human Services" OR "The Regents of the University of California") AND inv:"Donna M. HURYN" 第 1 页

1.

发明申请
PHENYL INDOLE ALLOSTERIC INHIBITORS OF P97 ATPASE 审中-公开

公开(公告)号：US20180319778A1

公开(公告)日：2018-11-08

申请号：US15769987

申请日：2016-10-20

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education , National Institute of Health, A Component of the U.S Department of Health and Human Services , The Regents of the University of California

发明人： Donna M. HURYN , Peter Wipf , Matthew G. LaPorte , Raffaele Colombo , Marina Kovaliov , Chaemin Lim , Celeste Natalie Alverez , Zhizhou Yue , Lalith Palitha Samankumara , Alexander Julian Chatterley , Yongzhao Yan , Mary Liang , Neal J. Green , Eric T. Baldwin , William J. Moore , Michelle Arkin , R. Jeffrey Neilz , Kean-Hooi Ang , Cliffford Bryant , Stacie Bulfer

IPC分类号： C07D405/14 , C07D401/14 , C07D401/10 , C07D413/14 , C07D417/14 , A61P25/28 , A61P35/00

CPC分类号： C07D405/14 , A61K31/404 , A61K31/454 , A61K31/496 , A61P25/28 , A61P35/00 , C07D401/10 , C07D401/14 , C07D413/14 , C07D417/14

摘要： The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.

2.

发明申请
MODULATORS OF P97 AAA ATPASE ACTIVITY 有权

公开(公告)号：US20210070732A1

公开(公告)日：2021-03-11

申请号：US17099514

申请日：2020-11-16

申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

发明人： Donna M. HURYN , Peter Wipf , Matthew G. LaPorte

IPC分类号： C07D401/04 , A61K45/06 , A61K31/4196 , A61K31/44 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14

摘要： The present invention is directed to methods of inhibiting or modulating p97 and compounds and compositions useful in such methods. Diseases and conditions that can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by modulation or inhibition of p97.

3.

发明申请
UTROPHIN UPREGULATION COMPOUNDS FOR DUCHENNE MUSCULAR DYSTROPHY THERAPY 有权

公开(公告)号：US20230076977A1

公开(公告)日：2023-03-09

申请号：US17792707

申请日：2021-01-14

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Tejvir S. KHURANA , Donna M. HURYN

IPC分类号： A61K31/165 , A61K31/18 , A61K31/343 , A61K31/4045 , A61K31/4184 , A61K31/423 , A61K31/44 , A61K31/519

摘要： The present invention provides methods for increasing expression of utrophin in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising a post-transcriptionally utrophin upregulator compound. The present invention also provides methods for treating a subject having a muscular dystrophy. This invention further provides methods for high-throughput screening for a post-transcriptional utrophin upregulator compound.