公开(公告)号：US10801027B2

公开(公告)日：2020-10-13

申请号：US16304487

申请日：2017-05-30

Applicant: University of Sheffield

Inventor： Guillaume Hautbergue ,  Mimoun Azzouz ,  Alexander Whitworth ,  Pamela Shaw

IPC: A61K48/00 ,  C07H21/04 ,  C12N15/113 ,  C12N9/12 ,  A61P35/00 ,  A61K38/00

Abstract: The present disclosure relates to antagonists that target Serine/Arginine-Rich Splicing Factor 1 (SRSF1); expression vectors comprising SRSF1 antagonists; and the use of such antagonists in therapy for the treatment of neurodegenerative disorders and cancer and screening methods that identify agents that inhibit the expression or activity of SRSF1.

公开(公告)号：US20190194660A1

公开(公告)日：2019-06-27

申请号：US16304487

申请日：2017-05-30

Applicant: University of Sheffield

Inventor： Guillaume Hautbergue ,  Mimoun Azzouz ,  Alexander Whitworth ,  Pamela Shaw

IPC: C12N15/113 ,  C12N9/12

CPC classification number: C12N15/113 ,  A61K38/00 ,  A61P35/00 ,  C12N9/1205 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2740/16043 ,  C12Y207/11001

Abstract: The present disclosure relates to antagonists that target Serine/Arginine-Rich Splicing Factor 1 (SRSF1); expression vectors comprising SRSF1 antagonists; and the use of such antagonists in therapy for the treatment of neurodegenerative disorders and cancer and screening methods that identify agents that inhibit the expression or activity of SRSF1.