公开(公告)号：US20240342111A1

公开(公告)日：2024-10-17

申请号：US18761018

申请日：2024-07-01

Applicant: University of South Carolina

Inventor： Sajish Mathew

IPC: A61K31/05 ,  A61K9/00

CPC classification number: A61K31/05 ,  A61K9/0053

Abstract: Described herein are mechanistic results showing that cis- and trans-RSV have opposite effects on TyrRS-regulated neuronal DNA repair and survival, mechanistically, only cis-RSV protected neurons against stress conditions by activating TyrRS-regulated neuronal DNA repair and resilient signaling; trans-RSV, conversely, facilitated the downregulation of TyrRS resulting in the accumulation of DNA damage and subsequent neurodegeneration. Knockdown of TyrRS blunted the neuroprotective effects of cis-RSV and exacerbated the neurotoxicity by trans-RSV, providing a potential molecular basis for the controversial effects of RSV in clinical studies. The disclosure also provides an oral dosage form comprising an amount of resveratrol comprising a therapeutically effective amount of cis-resveratrol and not more than 200 mg of trans-resveratrol.

公开(公告)号：US20230201133A1

公开(公告)日：2023-06-29

申请号：US17974680

申请日：2022-10-27

Applicant: University of South Carolina

Inventor： Sajish Mathew

IPC: A61K31/05 ,  A61P25/28

CPC classification number: A61K31/05 ,  A61P25/28

Abstract: Described herein are mechanistic results showing that cis- and trans-RSV have opposite effects on TyrRS-regulated neuronal DNA repair and survival, mechanistically, only cis-RSV protected neurons against stress conditions by activating TyrRS-regulated neuronal DNA repair and resilient signaling; trans-RSV, conversely, facilitated the downregulation of TyrRS resulting in the accumulation of DNA damage and subsequent neurodegeneration. Knockdown of TyrRS blunted the neuroprotective effects of cis-RSV and exacerbated the neurotoxicity by trans-RSV, providing a potential molecular basis for the controversial effects of RSV in clinical studies.