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公开(公告)号：US20240293047A1
公开(公告)日：2024-09-05
申请号：US18278549
申请日：2022-02-23
Applicant: University of Virginia Patent Foundation
Inventor： BORIS P. KOVATCHEV , MARC D. BRETON , CHIARA FABRIS , DAYU LV
CPC classification number: A61B5/14532 , A61B5/7264 , G16H10/20 , G16H20/17 , G16H50/20 , G16H50/50
Abstract: Provided are a method, system and computer-readable storage medium for quantitative physiological assessment and prediction of clinical subtypes of glucose metabolism disorders, including but not limited to, Type 1 diabetes, obesity, pre-diabetes, gestational diabetes, or variants of Type 2 diabetes. The method allows a virtual population of in silico entities to be created, reproducing faithfully the clinical subtype distributions observed in vivo. Potential applications of this method may include, but are not limited to: (a) enabling in silico experiments assessing and/or predicting, for a real patient, treatment or intervention outcomes for a given population/clinical-subtype level; (b) pre-clinical testing of properties of new medications; (c) augmenting limited clinical trial data with in silico experiments to an extent that the domain of their validity and test corner cases may not be observed in vivo.
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公开(公告)号：US20220395200A1
公开(公告)日：2022-12-15
申请号：US17776717
申请日：2020-11-16
Applicant: University of Virginia Patent Foundation
Inventor： BORIS P. KOVATCHEV , CHIARA FABRIS
Abstract: A method, system, and computer-readable medium for providing a real-time estimation of laboratory glycosylated hemoglobin (HbA1c) at one or more intervals. The real-time estimation is conferred as a value of estimated, time variable A1e (eA1c) based on daily continuous glucose monitoring (CGM)-derived time in target range (TIR) (CGM-TIR). The eA1c value is adjusted based on a sole laboratory HbA1c value for an interval preceding an interval corresponding to the eA1c value so as to provide an expected value for a laboratory HbA1c value at the same corresponding interval.
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