公开(公告)号：US20240335515A1

公开(公告)日：2024-10-10

申请号：US18577620

申请日：2022-07-12

Applicant: University of Washington

Inventor： ELIZABETH NANCE ,  ANDREA JOSEPH ,  CHRIS NYAMBURA ,  WALTER JAMES PFAENDTNER ,  THOMAS WOOD

IPC: A61K38/44 ,  A61K47/54 ,  A61K47/61 ,  A61P25/28 ,  C12N9/08 ,  C12N11/08

CPC classification number: A61K38/44 ,  A61K47/541 ,  A61K47/61 ,  A61P25/28 ,  C12N9/0065 ,  C12N11/08 ,  C12Y111/01006

Abstract: Enzyme-loaded polymeric nanoparticles for the treatment of disorders such as neurological or non-neurological conditions are described. Using hydrophobic ion pairing, enzymes are loaded into polymeric nanoparticles while retaining enzymatic activity. Surfactants coating the nanoparticle can direct nanoparticles for cellular uptake or for aggregation in the extracellular matrix. Preparing a hydrophobic ion pairing complex for nanoparticle formation.