公开(公告)号：US09999206B2

公开(公告)日：2018-06-19

申请号：US14341692

申请日：2014-07-25

Applicant: Utah State University

Inventor： Irina Polejaeva ,  Zhongde Wang ,  Shengwei Hu ,  Ravi Ranjan ,  Aaron James Thomas ,  Christopher Joseph Davies ,  Kenneth L. White

IPC: A01K67/00 ,  A01K67/027 ,  C07K14/495

CPC classification number: A01K67/0275 ,  A01K67/0278 ,  A01K2217/072 ,  A01K2217/206 ,  A01K2227/102 ,  A01K2267/0375 ,  C07K14/495

Abstract: Herein provided are a model and method for a transgenic a bovidae having an TGF-β1 gene inserted into the bovidae genome and capable of expressing higher than normal levels of TGF-β1 in cardiac muscle.

公开(公告)号：US20150033370A1

公开(公告)日：2015-01-29

申请号：US14341692

申请日：2014-07-25

Applicant: Utah State University

Inventor： Irina Polejaeva ,  Zhongde Wang ,  Shengwei Hu ,  Ravi Ranjan ,  Aaron James Thomas ,  Christopher Joseph Davies ,  Kenneth L. White

IPC: A01K67/027 ,  A61D19/04

CPC classification number: A01K67/0275 ,  A01K67/0278 ,  A01K2217/072 ,  A01K2217/206 ,  A01K2227/102 ,  A01K2267/0375 ,  C07K14/495

Abstract: Herein provided are a model and method for a transgenic a bovidae having an TGF-β1 gene inserted into the bovidae genome and capable of expressing higher than normal levels of TGF-β1 in cardiac muscle.

Abstract translation: 本文提供了一种用于转基因小鼠的模型和方法，其具有插入到bovidae基因组中并能够在心肌中表达高于正常水平的TGF-β1的TGF-β1基因。