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    SUBSTITUTED 3-BENZYLQUINOXALIN-4(3H)-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC ACETYCHOLINE RECEPTOR M1
    1.
    发明申请
    SUBSTITUTED 3-BENZYLQUINOXALIN-4(3H)-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC ACETYCHOLINE RECEPTOR M1 有权
    取代的3-苄氧基喹啉-4（3H） - 酮类似物作为MUSCARINIC乙酰胆碱受体M1的阳性免疫调节剂

    公开(公告)号：US20160102090A1

    公开(公告)日：2016-04-14

    申请号：US14787722

    申请日：2014-04-28

    Applicant: VANDERBILT UNIVERSITY

    Inventor： Craig W. Lindsley ,  P. Jeffrey Conn ,  Shaun R. Stauffer ,  Joseph David Panarese

    IPC: C07D471/04 ,  C07D401/10

    CPC classification number: C07D471/04 ,  C07D401/10 ,  C07D403/10

    Abstract: In one aspect, the invention relates to 3-benzylquinazolin-4(3H)-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

    Abstract translation: 一方面，本发明涉及可用作毒蕈碱乙酰胆碱受体M1（mAChR M1）的正变构调节剂的3-苄基喹唑啉-4（3H） - 酮类似物化合物及其衍生物及其相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物治疗与毒蕈碱性乙酰胆碱受体功能障碍相关的神经和精神疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

    Substituted quinazolin-4(3H)-ones, pyrido[3,4-d]pyrimidin-4(3H)-ones, pyrido[3,2-d]pyrimidin-4(3H)-ones and pyrido[2,3-d]pyrimidin-4(3H)-ones as positive allosteric modulators of muscarinic acetycholine receptor M1
    3.
    发明授权
    Substituted quinazolin-4(3H)-ones, pyrido[3,4-d]pyrimidin-4(3H)-ones, pyrido[3,2-d]pyrimidin-4(3H)-ones and pyrido[2,3-d]pyrimidin-4(3H)-ones as positive allosteric modulators of muscarinic acetycholine receptor M1 有权
    吡啶并[3,4-d]嘧啶-4（3H） - 酮，吡啶并[3,2-d]嘧啶-4（3H） - 酮和吡啶并[2,3- d]嘧啶-4（3H） - 酮作为毒蕈碱性乙酰胆碱受体M1的正变构调节剂

    公开(公告)号：US09540371B2

    公开(公告)日：2017-01-10

    申请号：US14787722

    申请日：2014-04-28

    Applicant: Vanderbilt University

    Inventor： Craig W. Lindsley ,  P. Jeffrey Conn ,  Shaun R. Stauffer ,  Joseph David Panarese

    IPC: A61K31/519 ,  C07D471/04 ,  C07D403/10 ,  C07D401/10

    CPC classification number: C07D471/04 ,  C07D401/10 ,  C07D403/10

    Abstract: In one aspect, the invention relates to 3-benzylquinazolin-4(3H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. Exemplary 3-benzylquinazolin-4(3H)-one compounds include compounds of formula (I):

    Abstract translation: 一方面，本发明涉及可用作毒蕈碱乙酰胆碱受体M1（mAChR M1）的正变构调节剂的3-苄基喹唑啉-4（3H） - 酮类似物化合物及其衍生物及其相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物治疗与毒蕈碱性乙酰胆碱受体功能障碍相关的神经和精神疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

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