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公开(公告)号：US09700558B2
公开(公告)日：2017-07-11
申请号：US14771109
申请日：2014-03-17
申请人： VERONA PHARMA PLC
IPC分类号： A61K31/519 , A61K31/46 , A61K31/40 , A61K45/06 , A61K9/00 , A61K31/137 , A61K31/167 , A61K31/44 , A61K9/48 , A61M15/00
CPC分类号： A61K31/519 , A61K9/0075 , A61K9/0078 , A61K9/008 , A61K9/0095 , A61K9/4858 , A61K31/137 , A61K31/167 , A61K31/40 , A61K31/44 , A61K31/46 , A61K45/06 , A61M15/009 , A61M2202/064 , A61K2300/00
摘要： The invention provides a composition which comprises (a) a PDE3/PDE4 inhibitor which is 9,10-Dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (b) a muscarinic receptor antagonist.
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公开(公告)号：US20160008363A1
公开(公告)日：2016-01-14
申请号：US14771097
申请日：2014-03-17
申请人： VERONA PHARMA PLC
IPC分类号： A61K31/519 , A61K9/00 , A61K31/44 , A61K31/137 , A61K31/167
CPC分类号： A61K31/519 , A61K9/0075 , A61K9/0078 , A61K9/008 , A61K9/0095 , A61K9/4858 , A61K31/137 , A61K31/167 , A61K31/40 , A61K31/44 , A61K31/46 , A61K45/06 , A61M15/009 , A61M2202/064 , A61K2300/00
摘要： The invention provides a composition which comprises (a) a PDE3/PDE4 inhibitor which is 9,10-Dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (b) a β2-adrenergic receptor agonist.
摘要翻译： 本发明提供一种组合物，其包含（a）PDE3 / PDE4抑制剂，其为9,10-二甲氧基-2-（2,4,6-三甲基苯基亚氨基）-3-（N-氨基甲酰基-2-氨基乙基）-3,4 ，6,7-四氢-2H-嘧啶并[6,1-a]异喹啉-4-酮或其药学上可接受的酸加成盐和（b）2-肾上腺素能受体激动剂。
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公开(公告)号：US20170266190A1
公开(公告)日：2017-09-21
申请号：US15614440
申请日：2017-06-05
申请人： VERONA PHARMA PLC
IPC分类号： A61K31/519 , A61M15/00 , A61K9/48 , A61K9/00 , A61K31/167 , A61K45/06 , A61K31/44 , A61K31/40 , A61K31/137 , A61K31/46
摘要： The invention provides a composition which comprises (a) a PDE3/PDE4 inhibitor which is 9,10-Dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (b) a muscarinic receptor antagonist.
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公开(公告)号：US20160000790A1
公开(公告)日：2016-01-07
申请号：US14771109
申请日：2014-03-17
申请人： VERONA PHARMA PLC
IPC分类号： A61K31/519 , A61M15/00 , A61K45/06
CPC分类号： A61K31/519 , A61K9/0075 , A61K9/0078 , A61K9/008 , A61K9/0095 , A61K9/4858 , A61K31/137 , A61K31/167 , A61K31/40 , A61K31/44 , A61K31/46 , A61K45/06 , A61M15/009 , A61M2202/064 , A61K2300/00
摘要： The invention provides a composition which comprises (a) a PDE3/PDE4 inhibitor which is 9,10-Dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (b) a muscarinic receptor antagonist.
摘要翻译： 本发明提供一种组合物，其包含（a）PDE3 / PDE4抑制剂，其为9,10-二甲氧基-2-（2,4,6-三甲基苯基亚氨基）-3-（N-氨基甲酰基-2-氨基乙基）-3,4 ，6,7-四氢-2H-嘧啶并[6,1-a]异喹啉-4-酮或其药学上可接受的酸加成盐和（b）毒蕈碱受体拮抗剂。
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公开(公告)号：US10471063B2
公开(公告)日：2019-11-12
申请号：US15614440
申请日：2017-06-05
申请人： VERONA PHARMA PLC
IPC分类号： A61K31/519 , A61K31/40 , A61K45/06 , A61K9/00 , A61K31/137 , A61K31/167 , A61K31/44 , A61K31/46 , A61K9/48 , A61M15/00
摘要： The invention provides a composition which comprises (a) a PDE3/PDE4 inhibitor which is 9,10-Dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (b) a muscarinic receptor antagonist.
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公开(公告)号：US09717732B2
公开(公告)日：2017-08-01
申请号：US14771097
申请日：2014-03-17
申请人： VERONA PHARMA PLC
IPC分类号： A61K31/505 , A61K31/519 , A61K31/40 , A61K45/06 , A61K9/00 , A61K31/137 , A61K31/167 , A61K31/44 , A61K31/46 , A61K9/48 , A61M15/00
CPC分类号： A61K31/519 , A61K9/0075 , A61K9/0078 , A61K9/008 , A61K9/0095 , A61K9/4858 , A61K31/137 , A61K31/167 , A61K31/40 , A61K31/44 , A61K31/46 , A61K45/06 , A61M15/009 , A61M2202/064 , A61K2300/00
摘要： The invention provides a composition which comprises (a) a PDE3/PDE4 inhibitor which is 9,10-Dimethoxy-2-(2,4,6-trimethylphenylimino)-3-(N-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one or a pharmaceutically acceptable acid addition salt thereof and (b) a β2-adrenergic receptor agonist.
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