公开(公告)号：US20230373925A1

公开(公告)日：2023-11-23

申请号：US18137939

申请日：2023-04-21

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Mark Thomas Miller ,  Dennis James Hurley ,  Timothy Donald Neubert ,  Vijayalaksmi Arumugam ,  Sara Sabina Hadida Ruah ,  Jason McCartney ,  Jinglan ZHOU ,  Jaclyn Chau ,  Robert Martin Demoret ,  Senait G. Ghirmai ,  Roman Askatovich Valiulin ,  Alexander Frederik Kintzer ,  David Robert Slochower ,  Kathleen Aertgeerts ,  Elizabeth Mary Beck ,  James Jun Bon Mui ,  Miranda Adele Wright ,  Ronald Marcellus Alphonsus Knegtel ,  Ewa Iwona Chudyk ,  Joanne Louise Pinder ,  James Dodd

IPC分类号： C07D215/233 ,  C07D471/04 ,  C07D239/91 ,  C07D401/14 ,  C07D401/04 ,  C07D519/00

CPC分类号： C07D215/233 ,  C07D471/04 ,  C07D239/91 ,  C07D401/14 ,  C07D401/04 ,  C07D519/00 ,  C07B2200/05

摘要： Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.