公开(公告)号：US11464774B2

公开(公告)日：2022-10-11

申请号：US15763366

申请日：2016-09-30

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： John Robert Pollard ,  Peter Littlewood ,  Philip Michael Reaper ,  Mohammed Asmal ,  Scott Zachary Fields

IPC分类号： A61K31/497 ,  A61K33/243 ,  A61P35/00 ,  A61K45/06 ,  A61K31/7068 ,  A61K31/4965 ,  A61K31/555 ,  A61K31/519 ,  A61K31/282 ,  A61N5/10

摘要： Described herein are methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a DNA damaging agent and between about 12 and about 48 hours later administering to the subject a compound that inhibits ATR protein kinase. Methods of treating a proliferative disorder (e.g., cancer) in a patient by administering a compound that inhibits ATR protein kinase are also described. Exemplary ATR inhibitors are represented by Formulae A-I and A-II or a pharmaceutically acceptable salt thereof, wherein the variables are as defined herein.