公开(公告)号：US11197798B2

公开(公告)日：2021-12-14

申请号：US15359731

申请日：2016-11-23

申请人： VIBRANT LTD.

发明人： Shaul Shohat ,  Alexander Belenky ,  Roni Shabat

IPC分类号： A61H23/02

摘要： An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (GI) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the GI wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by an agitation mechanism embedded in the GIC. Such agitation mechanism includes an unbalanced weight attached to the shaft of an electric motor, an actuator implemented by, such as an electric solenoid, an electro-active polymer (EAP), a dielectric elastomer actuator (DEA), embedded in a GIC of the invention.

公开(公告)号：US09532923B2

公开(公告)日：2017-01-03

申请号：US14732733

申请日：2015-06-07

申请人： VIBRANT LTD.

发明人： Shaul Shohat ,  Alexander Belenky ,  Roni Shabat

IPC分类号： A61H23/00 ,  A61H23/02

CPC分类号： A61H23/0263 ,  A61H23/02 ,  A61H2205/083

摘要： An ingestible gastrointestinal capsule (GIC) for mechanically stimulating a segment of the gastrointestinal (GI) wall by alternately and repeatedly pressurizing, and/or vibrating it is provided. The GIC is programmed to being activated following a predefined time delay. The activated GIC agitates, shakes, rattles, jolts, vibrates and/or moves in a reciprocal expanding and contracting motion thereby mechanically stimulating the adjacent segment of the GI wall at a targeted location. Activation of the GIC may include a number of automatically accomplished partial activations, such as when the time elapsed from the moment of setting the GIC on equals a predefined time delay; when the mechanical load applied onto the GIC exceeds, and/or gets lower than a respective predefined level of mechanical load; when the ambient pH reaches a predefined level, or changes, and/or a temperature associated with the user reaches a predefined threshold. Agitation is accomplished by means of agitation means embedded in the GIC. Such agitation means includes an unbalanced weight attached to the shaft of an electric motor, an actuator implemented by, such as an electric solenoid, an electro-active polymer (EAP), a dielectric elastomer actuator (DEA), embedded in a GIC of the invention.

摘要翻译： 提供了用于通过交替地和反复地加压和/或振动来机械刺激胃肠（GI）壁的一部分的可摄入胃肠胶囊（GIC）。 GIC被编程为在预定义的时间延迟之后被激活。 激活的GIC搅动，摇动，摇晃，颠簸，振动和/或以往复的扩张和收缩运动移动，从而机械刺激位于目标位置的GI壁的相邻部分。 GIC的激活可以包括许多自动完成的部分激活，例如当从设置GIC开始的时刻经过等于预定时间延迟的时间时; 当施加到GIC上的机械载荷超过和/或变得低于相应的预定水平的机械载荷时; 当环境pH达到预定义的水平或变化时，和/或与用户相关联的温度达到预定阈值。 搅拌是通过嵌入GIC中的搅拌装置来实现的。 这种搅拌装置包括附接到电动机的轴的不平衡重物，通过电螺线管实现的致动器，电活性聚合物（EAP），介电弹性体致动器（DEA），其嵌入在GIC中 发明。