公开(公告)号：US20240226127A1

公开(公告)日：2024-07-11

申请号：US18287722

申请日：2022-04-21

Applicant: VIGONVITA LIFE SCIENCES CO., LTD.

Inventor： Yang LEI ,  Gang CAO ,  Rong HU

IPC: A61K31/7052 ,  A61K31/14 ,  C07H17/02

CPC classification number: A61K31/7052 ,  A61K31/14 ,  C07H17/02

Abstract: The present disclosure relates to a nucleoside compound and an application thereof in the treatment of feline infectious peritonitis. The compound belongs to the GS-441524 analogues. The compound has little toxic effect on normal cat cells, while it has a significant inhibitory effect on feline coronavirus. The compound can be used to prepare feline coronavirus inhibitors for the treatment of feline infectious peritonitis. It has the advantages of good curative effect, high safety, and excellent water solubility, which makes it easier to be absorbed.