-
![5-(n-[6,5]-fused bicyclic aryl tetrahydroisoquinolin-6-yl) pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication](/abs-image/US/2020/03/03/US10577353B2/abs.jpg.150x150.jpg)
公开(公告)号：US10577353B2
公开(公告)日：2020-03-03
申请号：US15749144
申请日：2016-08-10
发明人： John F. Kadow , B. Narasimhulu Naidu , Tao Wang , Zhiwei Yin , Zhongxing Zhang
IPC分类号： C07D401/14 , C07D403/14 , C07D473/16 , C07D471/04 , C07D513/04 , C07D487/04 , C07D495/04 , C07D417/14 , C07D473/18 , A61K31/4427 , A61P31/18 , A61K31/5365
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
-
2.发明授权公开(公告)号：US10407410B2
公开(公告)日：2019-09-10
申请号：US16094536
申请日：2017-05-09
发明人： John F. Kadow , B. Narasimhulu Naidu , Manoj Patel , Michael A. Walker , Tao Wang , Zhiwei Yin , Zhongxing Zhang , Zhizhen Barbara Zheng
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D407/14 , C07D409/14 , C07D417/14 , A61P31/18 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/5365 , C07D411/14
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
-
公开(公告)号：US09586957B2
公开(公告)日：2017-03-07
申请号：US14779648
申请日：2014-03-25
发明人： Tao Wang , Zhiwei Yin , Zhongxing Zhang , John A. Bender , Barry L. Johnson , John F. Kadow , Nicholas A. Meanwell
IPC分类号： A61K31/55 , C07D471/04 , A61K45/06 , A61K31/437 , C07D401/06 , A61K31/4545 , A61K31/454 , C07D519/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/55 , A61K45/06 , C07D401/06 , C07D519/00
摘要： Compounds of Formula I, including pharmaceutically acceptable salts thereof: I useful as HIV attachment inhibitors.
摘要翻译： 式I的化合物，包括其药学上可接受的盐：可用作HIV附着抑制剂。
-
公开(公告)号：US20190092754A1
公开(公告)日：2019-03-28
申请号：US16202653
申请日：2018-11-28
发明人： Kyle J. EASTMAN , John F. Kadow , Kyle E. Parcella , B. Narasimhulu Naidu , Tao Wang , Zhiwei Yin , Zhongxing Zhang
IPC分类号： C07D401/14 , C07D401/04 , A61K31/444 , A61P31/18
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
-
公开(公告)号：US09834566B2
公开(公告)日：2017-12-05
申请号：US15119431
申请日：2015-02-13
发明人： John F. Kadow , B. Narasimhulu Naidu , Manoj Patel , Kevin Peese , Tao Wang , Zhiwei Yin , Zhongxing Zhang
IPC分类号： C07D498/16 , C07D498/22 , A61K31/519 , A61K45/06
CPC分类号： C07D498/16 , A61K31/519 , A61K45/06 , C07D498/22
摘要： The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.
-
公开(公告)号：US09655888B2
公开(公告)日：2017-05-23
申请号：US14419564
申请日：2013-08-07
发明人： Tao Wang , John F. Kadow , Nicholas A. Meanwell , Zhongxing Zhang , Zhiwei Yin , Edward H. Ruediger , Clint A. James , Daniel H. Deon
IPC分类号： C07D471/04 , C07D401/06 , A61K31/4545 , C07D401/14 , A61K31/454 , A61K45/06
CPC分类号： A61K31/4545 , A61K31/454 , A61K45/06 , C07D401/06 , C07D401/14 , C07D471/04
摘要： Compounds of Formula (I), including pharmaceutically acceptable salts thereof: wherein A is selected from the group consisting of: and wherein Z is: are useful as HIV attachment inhibitors.
-
公开(公告)号：US10214516B2
公开(公告)日：2019-02-26
申请号：US15749189
申请日：2016-08-10
发明人： John F. Kadow , B. Narasimhulu Naidu , Tao Wang , Zhiwei Yin , Zhongxing Zhang
IPC分类号： C07D403/14 , C07D401/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/147 , C07D495/04 , C07D513/14 , A61P31/18 , A61K31/5365
摘要： Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
-
公开(公告)号：US10189816B2
公开(公告)日：2019-01-29
申请号：US15749176
申请日：2016-08-10
发明人： Kyle J. Eastman , John F. Kadow , Kyle E. Parcella , B. Narasimhulu Naidu , Tao Wang , Zhiwei Yin , Zhongxing Zhang
IPC分类号： A61K31/444 , C07D401/02 , C07D401/14 , C07D401/04 , A61P31/18 , A61K31/5365
摘要： Disclosed are compounds of Formula (I), including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS. In the compounds of formula (I), R1 is selected from hydrogen, alkyl, or cycloalkyl; R2 is selected from tetrahydroisoquinolinyl and is substituted with 1 R6 substituent and also with 0-3 halo or alkyl substituents; R3 is selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy, and haloalkoxy; R4 is selected from alkyl or haloalkyl; R5 is alkyl; R6 is selected from Ar1, (Ar1)alkyl, (chromanyl)alkyl, cyanocycloalkyl or (dihydrobenzodioxinyl)alkyl; and Ar1 is phenyl substituted with 0-5 substituents selected from cyano, halo, alkyl, cycloalkyl, haloalkyl, hydroxy, alkoxy, haloalkoxy, (hydroxy)alkoxy, (alkoxy)alkoxy, phenoxy, benzyloxy, carboxy, phenyl, and cyanocycloalkyl.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.015 秒)
