公开(公告)号：US20220119794A1

公开(公告)日：2022-04-21

申请号：US17419274

申请日：2019-12-23

Applicant: VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY

Inventor： Liwu LI ,  Shuo GENG ,  Yao ZHANG

IPC: C12N15/01 ,  C12N15/85 ,  A61K35/15 ,  A61K31/192 ,  A61P29/00 ,  A61P9/10

Abstract: Described herein are embodiments of chemically modified neutrophils and pharmaceutical formulations thereof. Also described herein are 4-phenylbutyrate pharmaceutical formulations. Also described herein are methods of chemically modifying neutrophils. Also described herein are treatments for non-resolving inflammation and/or related diseases or conditions, including but not limited to atherosclerosis, cardiovascular disease, stroke, myocardial infarction, neurological disease, and/or a symptom thereof in a subject in need thereof.