公开(公告)号：US20240252553A1

公开(公告)日：2024-08-01

申请号：US18578856

申请日：2022-07-12

申请人： VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

发明人： Bahareh BEHKAM ,  Eric LEAMAN

IPC分类号： A61K35/74 ,  A61K45/06 ,  A61P35/00 ,  C12N9/52 ,  C12N15/74

CPC分类号： A61K35/74 ,  A61K45/06 ,  A61P35/00 ,  C12N9/52 ,  C12N15/74 ,  C12Y304/24003

摘要： Cancer is a significant cause of mortality and morbidity worldwide. One of the principal impediments to the broad success of conventional chemotherapy is poor delivery to and transport within the tumor microenvironment (TME), caused by irregular and leaky vasculature, the lack of functional lymphatics, and underscored by the overproduction of extracellular matrix (ECM) proteins such as collagen. Described herein are engineered Salmonella Typhimurium (S. Typhimurium) bacteria and uses thereof. In some embodiments, the engineered S. Typhimurium bacteria comprises an exogenous collagenase. Also described in exemplary embodiments herein methods of using the engineered S. Typhimurium bacteria, such as part of a,cancer therapy.