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公开(公告)号:US20110230669A1
公开(公告)日:2011-09-22
申请号:US12879241
申请日:2010-09-10
申请人: VOLKER KRAFT , GERHARD KRETZSCHMAR , KAI ROSSEN
发明人: VOLKER KRAFT , GERHARD KRETZSCHMAR , KAI ROSSEN
IPC分类号: C07D493/18 , C07C51/36 , C07C67/303
CPC分类号: C07C51/36 , C07B2200/07 , C07C67/303 , C07C2602/28 , C07D493/18 , C07D493/20 , C07C57/26 , C07C69/608
摘要: This application relates to a process for the production of (2R)-dihydroartemisinic acid or (2R)-dihydroartemisinic acid esters from artemisinic acid or artemisinic acid esters, respectively, by diimine hydrogenation of the exocyclic CC-double bond, and use of said process in the production of the antimalarial drug artemisinin.
摘要翻译: 本申请涉及分别通过外环CC-双键的二亚胺氢化从青蒿酸或青蒿酸酯制备(2R) - 二氢青蒿酸或(2R) - 二氢青蒿酸酯的方法,以及使用所述方法 在抗疟药物青蒿素的生产中。