公开(公告)号：US20220064671A1

公开(公告)日：2022-03-03

申请号：US17423737

申请日：2020-01-17

申请人： VOYAGER THERAPEUTICS, INC.

发明人： Luis Maranga ,  Christopher J. Morrison ,  Krishanu Mathur ,  Matthew Luther ,  Daniel S. Hurwit ,  Jacob J. Cardinal ,  Lori B. Karpes ,  Aditya Ansondaria ,  James Forster ,  David Dismuke ,  Robert Steininger

IPC分类号： C12N15/86 ,  A61K48/00

摘要： The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles, comprising recombinant adeno-associated virus (rAAV) particles. In certain embodiments, the production process and system use Sf9 insect cells as viral production cells. In certain embodiments, the production process and system use Baculoviral Expression Vectors (BEVs) and Baculoviral Infected Insect Cells (BIICs) in the production of AAV particles.