公开(公告)号：US20100075367A1

公开(公告)日：2010-03-25

申请号：US12591749

申请日：2009-11-30

申请人： Vadivel Masilamani ,  Masilamani Elangovan ,  Mohamad Alsalhi ,  Abdulrahman Al-Diab

发明人： Vadivel Masilamani ,  Masilamani Elangovan ,  Mohamad Alsalhi ,  Abdulrahman Al-Diab

IPC分类号： C12Q1/02 ,  G01N21/64

CPC分类号： G01N33/57423 ,  G01N2800/50 ,  G01N2800/56

摘要： The method for lung cancer detection by optical analysis of body fluids relates to analyzing samples of blood, urine and sputum by fluorescence spectroscopy in order to detect the presence of naturally occurring molecules in the fluids that serve as biomarkers indicative of cancer in the human body. The analysis can be carried out based on fluorescence emission spectra, fluorescence excitation spectra and synchronous (emission and excitation) spectra of bio-samples. The early detection and diagnosis of lung cancer may be made by comparison of ratios of fluorescence emissions and/or excitation intensities of tryptophan, tyrosine, elastin, collagen, bile pigments, NADPH, flavins and various species of porphyrins.

摘要翻译： 通过体液光学分析进行肺癌检测的方法涉及通过荧光光谱法分析血液，尿液和痰液的样品，以便检测作为指示人体癌症的生物标志物的流体中天然存在的分子的存在。 该分析可以基于荧光发射光谱，荧光激发光谱和生物样品的同步（发射和激发）光谱进行。 可以通过比较色氨酸，酪氨酸，弹性蛋白，胶原，胆汁颜料，NADPH，黄素和各种卟啉的荧光发射和/或激发强度的比例来进行肺癌的早期检测和诊断。