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公开(公告)号：US07629458B2
公开(公告)日：2009-12-08
申请号：US10263192
申请日：2002-10-03
IPC分类号： C07D498/06
CPC分类号： C07D498/06
摘要： The invention provides a method for preparing levofloxacin hemihydrate, comprising: maintaining levofloxacin at a first elevated temperature in a first solvent; adding a polar solvent to precipitate the levofloxacin hemihydrate, wherein the polar solvent comprises water; and recovering the levofloxacin hemihydrate. The invention also provides a method of converting a levofloxacin form to levofloxacin hemihydrate, comprising storing one or more forms selected from the group consisting of Forms A, B, C, F, G and H for a sufficient time to permit the one or more forms to convert to levofloxacin hemihydrate.
摘要翻译： 本发明提供了一种制备左氧氟沙星半水合物的方法，其包括：在第一溶剂中保持左氧氟沙星在第一升高温度; 加入极性溶剂以沉淀左氧氟沙星半水合物，其中极性溶剂包括水; 并回收左氧氟沙星半水合物。 本发明还提供了将左氧氟沙星形式转化为左氧氟沙星半水合物的方法，包括将一种或多种选自形式A，B，C，F，G和H的形式储存足够的时间以允许一种或多种形式 转化为左氧氟沙星半水合物。
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公开(公告)号：US20050222409A1
公开(公告)日：2005-10-06
申请号：US11137348
申请日：2005-05-26
IPC分类号： A61K31/5383 , A61P31/04 , B01D9/02 , C07D498/06 , A61K31/538 , C07D491/14
CPC分类号： C07D498/06
摘要： Levofloxacin was prepared by reacting (S)-(−)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid with N-methyl piperazine in a polar solvent or in a neat mixture to form levofloxacin. Further processing of the levofloxacin produced novel levofloxacin forms, including a hemihydrate and Forms A, B, C, F, G and H.
摘要翻译： （S） - （ - ） - 9,10-二氟-3-甲基-7-氧代-2,3-二氢-7H-吡啶并[1,2,3-de] [1,4] 苯并恶嗪-6-羧酸与N-甲基哌嗪在极性溶剂中或在纯的混合物中形成左氧氟沙星。 左氧氟沙星的进一步加工产生新的左氧氟沙星形式，包括半水合物和形式A，B，C，F，G和H.
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公开(公告)号：US07423153B2
公开(公告)日：2008-09-09
申请号：US10436736
申请日：2003-05-12
IPC分类号： C07D401/04 , A61K31/47
CPC分类号： C07D215/56
摘要： Provided are novel crystalline forms of gatifloxacin denominated forms A, B, C, D, E1, F, G, H, I, and J, and methods for their preparation. Also provided are methods for making known crystalline forms of gatifloxacin, in particular forms omega and T2RP.
摘要翻译： 提供加替沙星命名形式为A，B，C，D，E1，F，G，H，I和J的新型结晶形式及其制备方法。 还提供了制备加替沙星的已知结晶形式的方法，特别是形成ω和T2RP。
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公开(公告)号：US07411067B2
公开(公告)日：2008-08-12
申请号：US10462945
申请日：2003-06-16
IPC分类号： C07D401/04 , A61K31/47
CPC分类号： C07D215/56 , C07D401/04
摘要： Provided are two novel crystalline forms of gatifloxacin, denominated form O and form V, and methods for their preparation.
摘要翻译： 提供加替沙星的两种新型结晶形式，称为O型和V型，其制备方法。
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公开(公告)号：US20060252770A1
公开(公告)日：2006-11-09
申请号：US11488810
申请日：2006-07-17
IPC分类号： A61K31/496 , C07D403/02
CPC分类号： C07D215/56
摘要： Provided are novel crystalline forms of gatifloxacin, some of which are DMSO solvates, and methods for making them.
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公开(公告)号：US20050288302A1
公开(公告)日：2005-12-29
申请号：US11208299
申请日：2005-08-19
IPC分类号： C07D215/56 , A61K31/496 , C07D43/02
CPC分类号： C07D215/56
摘要： Provided are novel crystalline forms of gatifloxacin denominated forms A, B, C, D, E1, F, G, H, I, and J, and methods for their preparation. Also provided are methods for making known crystalline forms of gatifloxacin, in particular forms omega and T2RP.
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公开(公告)号：US20060258674A1
公开(公告)日：2006-11-16
申请号：US11488367
申请日：2006-07-17
IPC分类号： A61K31/496 , C07D403/02
CPC分类号： C07D215/56
摘要： Provided are novel crystalline forms of gatifloxacin, some of which are DMSO solvates, and methods for making them.
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公开(公告)号：US20060252772A1
公开(公告)日：2006-11-09
申请号：US11488812
申请日：2006-07-17
IPC分类号： A61K31/496 , C07D403/02
CPC分类号： C07D215/56
摘要： Provided are novel crystalline forms of gatifloxacin, some of which are DMSO solvates, and methods for making them.
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公开(公告)号：US20060252771A1
公开(公告)日：2006-11-09
申请号：US11488811
申请日：2006-07-17
IPC分类号： A61K31/496 , C07D403/02
CPC分类号： C07D215/56
摘要： Provided are novel crystalline forms of gatifloxacin, some of which are DMSO solvates, and methods for making them.
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公开(公告)号：US20050288301A1
公开(公告)日：2005-12-29
申请号：US11208248
申请日：2005-08-19
IPC分类号： C07D215/56 , A61K31/496 , C07D43/02
CPC分类号： C07D215/56
摘要： Provided are novel crystalline forms of gatifloxacin denominated forms A, B, C, D, E1, F, G, H, I, and J, and methods for their preparation. Also provided are methods for making known crystalline forms of gatifloxacin, in particular forms omega and T2RP.
摘要翻译： 提供加替沙星命名形式为A，B，C，D，E1，F，G，H，I和J的新型结晶形式及其制备方法。 还提供了制备加替沙星的已知结晶形式的方法，特别是形成ω和T2RP。
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