公开(公告)号：US11524966B1

公开(公告)日：2022-12-13

申请号：US16637692

申请日：2018-08-09

申请人： Valo Early Discovery, Inc.

发明人： David J. Guerin ,  Pui Yee Ng ,  Zhongguo Wang ,  Tatiana Shelekhin ,  Justin Caravella ,  Hongbin Li ,  Stephanos Ioannidis ,  Mary-Margaret Zablocki

IPC分类号： C07D495/04 ,  C07D519/00

摘要： The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments.

公开(公告)号：US10889592B2

公开(公告)日：2021-01-12

申请号：US16077406

申请日：2017-02-13

申请人： VALO EARLY DISCOVERY, INC.

发明人： David Joseph Guerin ,  Kenneth W. Bair ,  Justin A. Caravella ,  Stephanos Ioannidis, Jr. ,  David R. Lancia, Jr. ,  Hongbin Li ,  Steven Mischke ,  Pui Yee Ng ,  David Richard ,  Shawn E. R. Schiller ,  Tatiana Shelekhin ,  Zhongguo Wang

IPC分类号： C07D495/04

摘要： The disclosure relates to inhibitors of USP28 and/or USP25 useful in the treatment of cancers, inflammation, autoimmune diseases, and infectious diseases, having the Formula: (I), where R1, R2, R3, R4, R4′, R5, R6, X, and n are described herein.

公开(公告)号：US20210047343A1

公开(公告)日：2021-02-18

申请号：US17003356

申请日：2020-08-26

申请人： VALO EARLY DISCOVERY, INC.

发明人： David Joseph Guerin ,  Kenneth W. Bair ,  Justin A. Caravella ,  Stephanos Ioannidis ,  David R. Lancia, JR. ,  Hongbin Li ,  Steven Mischke ,  Pui Yee Ng ,  David Richard ,  Shawn E.R. Schiller ,  Tatiana Shelekhin ,  Zhongguo Wang

IPC分类号： C07D495/04

摘要： The disclosure relates to inhibitors of USP28 and/or USP25 useful in the treatment of cancers, inflammation, autoimmune diseases, and infectious diseases, having the Formula: (I), where R1, R2, R3, R4, R4′, R5, R6, X, and n are described herein.