公开(公告)号：US10160763B2

公开(公告)日：2018-12-25

申请号：US15703289

申请日：2017-09-13

Applicant: Vanderbilt University

Inventor： Stephen W. Fesik ,  Shaun R. Stauffer ,  William P. Tansey ,  Edward T. Olejniczak ,  Jason Phan ,  Feng Wang ,  KyuOk Jeon ,  Rocco D. Gogliotti

IPC: C07D487/04 ,  C07B59/00

Abstract: Described are compounds that disrupt the WDR5-MLL1 protein-protein interaction, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.

公开(公告)号：US20180086767A1

公开(公告)日：2018-03-29

申请号：US15703289

申请日：2017-09-13

Applicant: Vanderbilt University

Inventor： Stephen W. Fesik ,  Shaun R. Stauffer ,  William P. Tansey ,  Edward T. Olejniczak ,  Jason Phan ,  Feng Wang ,  KyuOk Jeon ,  Rocco D. Gogliotti

IPC: C07D487/04 ,  C07B59/00

CPC classification number: C07D487/04 ,  C07B59/002 ,  C07B2200/05

Abstract: Described are compounds that disrupt the WDR5-MLL1 protein-protein interaction, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.

公开(公告)号：US20190084988A1

公开(公告)日：2019-03-21

申请号：US16135729

申请日：2018-09-19

Applicant: Vanderbilt University

Inventor： Stephen W. Fesik ,  Shaun R. Stauffer ,  James M. Salovich ,  William P. Tansey ,  Feng Wang ,  Jason Phan ,  Edward T. Olejniczak

IPC: C07D487/04 ,  A61P35/02

Abstract: Described are N-(6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-2,3-dihydro-1H-inden-1-yl)benzamide and acetamide-containing compounds that inhibit WDR5 and associated protein-protein interactions, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.