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1.发明申请ENHANCED PRODUCTION OF TAXOL AND TAXANES BY CELL CULTURES OF TAXUS SPECIES 失效通过细菌培养物种增强TAXOL和TAXANES的生产公开(公告)号：US20110086397A1
公开(公告)日：2011-04-14
申请号：US12972064
申请日：2010-12-17
IPC分类号： C12P17/02
CPC分类号： C12N5/0025 , C12P15/00 , C12P17/02
摘要： This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T. chinensis is particularly enhanced by use of one or more of these conditions, yield of taxanes for all Taxus species has been found to benefit from use of these conditions.
摘要翻译： 本发明提供了可以从所有已知的紫杉属物种（例如短枝红，加拿大，西葫芦，芽孢杆菌，球形花粉，花蓟马，堇菜，培养基）中以非常高的产量生产紫杉醇，浆果赤霉素III和其他紫杉醇样化合物或紫杉烷类的方法 和中华。 已经发现了培养条件（即培养基组成和操作模式）的特殊修饰，以提高所有紫杉属种类细胞培养物中各种紫杉烷的产量。 特别优选的增强剂包括银离子或络合物，茉莉酸（特别是甲酯），生长素相关的生长调节剂和苯丙素途径的抑制剂，如3,4-亚甲二氧基-6-硝基肉桂酸。 这些增强剂可以单独使用或彼此组合使用或其它收率增强条件使用。 通过使用这些条件中的一种或多种，特别地增强了来自中华根瘤菌植物细胞培养物的紫杉烷的产率，已经发现所有紫杉属物种的紫杉烷的产率受益于使用这些条件。
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2.发明授权Enhanced production of taxol and taxanes by cell cultures of Taxus species 失效通过红豆杉种细胞培养增强紫杉醇和紫杉烷的生产公开(公告)号：US07264951B1
公开(公告)日：2007-09-04
申请号：US09083198
申请日：1998-05-22
IPC分类号： C12P17/02
摘要： This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T. chinensis is particularly enhanced by use of one or more of these conditions, yield of taxanes for all Taxus species has been found to benefit from use of these conditions.
摘要翻译： 本发明提供了可以从所有已知的紫杉属物种（例如短枝红，加拿大，西葫芦，芽孢杆菌，球形花粉，花蓟马，堇菜，培养基）中以非常高的产量生产紫杉醇，浆果赤霉素III和其他紫杉醇样化合物或紫杉烷类的方法 和中华。 已经发现了培养条件（即培养基组成和操作模式）的特殊修饰，以提高所有紫杉属种类细胞培养物中各种紫杉烷的产量。 特别优选的增强剂包括银离子或络合物，茉莉酸（特别是甲酯），生长素相关的生长调节剂和苯丙素途径的抑制剂，如3,4-亚甲二氧基-6-硝基肉桂酸。 这些增强剂可以单独使用或彼此组合使用或其它收率增强条件使用。 通过使用这些条件中的一种或多种，特别地增强了来自中华根瘤菌植物细胞培养物的紫杉烷的产率，已经发现所有紫杉属物种的紫杉烷的产率受益于使用这些条件。
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3.发明申请ENHANCED PRODUCTION OF TAXOL AND TAXANES BY CELL CULTURES OF TAXUS SPECIES 审中-公开通过细菌培养物种增强紫杉醇和紫杉醇的生产公开(公告)号：US20130017582A1
公开(公告)日：2013-01-17
申请号：US13618284
申请日：2012-09-14
IPC分类号： C12P17/02
CPC分类号： C12N5/0025 , C12P15/00 , C12P17/02
摘要： This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T. chinensis is particularly enhanced by use of one or more of these conditions, yield of taxanes for all Taxus species has been found to benefit from use of these conditions.
摘要翻译： 本发明提供了可以从所有已知的紫杉属物种（例如短枝红，加拿大，西葫芦，芽孢杆菌，球形花粉，花蓟马，堇菜，培养基）中以非常高的产量生产紫杉醇，浆果赤霉素III和其他紫杉醇样化合物或紫杉烷类的方法 和中华。 已经发现了培养条件（即培养基组成和操作模式）的特殊修饰，以提高所有紫杉属种类细胞培养物中各种紫杉烷的产量。 特别优选的增强剂包括银离子或络合物，茉莉酸（特别是甲酯），生长素相关的生长调节剂和苯丙素途径的抑制剂，如3,4-亚甲二氧基-6-硝基肉桂酸。 这些增强剂可以单独使用或彼此组合使用或其它收率增强条件使用。 通过使用这些条件中的一种或多种，特别地增强了来自中华根瘤菌植物细胞培养物的紫杉烷的产率，已经发现所有紫杉属物种的紫杉烷的产率受益于使用这些条件。
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