公开(公告)号：US07189853B2

公开(公告)日：2007-03-13

申请号：US10932562

申请日：2004-09-02

申请人： Venkataraman Sundaram ,  Srinivasan Thirumalai Rajan ,  Veera Venkata Naga Chandra Sekhar Bulusu ,  AlokKumar Srivastav ,  Ravi Kumar Kasturi ,  Sanjeev Kumar Aavula

发明人： Venkataraman Sundaram ,  Srinivasan Thirumalai Rajan ,  Veera Venkata Naga Chandra Sekhar Bulusu ,  AlokKumar Srivastav ,  Ravi Kumar Kasturi ,  Sanjeev Kumar Aavula

IPC分类号： C07D215/18

CPC分类号： C07D215/18

摘要： The present invention is related to a process for preparing montelukast involving the compound of formula (VI): wherein X═CN or CONH2.

摘要翻译： 本发明涉及涉及式（VI）化合物的孟鲁司特的制备方法：其中X-CN或CONH 2'。

公开(公告)号：US20100063291A1

公开(公告)日：2010-03-11

申请号：US12619736

申请日：2009-11-17

申请人： Buchi Reddy Reguri ,  Satyanarayana Bollikonda ,  Veera Venkata Naga Chandra Sekhar Bulusu ,  Ravi Kumar Kasturi ,  Sanjeev Kumar Aavula

发明人： Buchi Reddy Reguri ,  Satyanarayana Bollikonda ,  Veera Venkata Naga Chandra Sekhar Bulusu ,  Ravi Kumar Kasturi ,  Sanjeev Kumar Aavula

IPC分类号： C07D215/14

CPC分类号： C07D215/18

摘要： A process for preparation of montelukast or a salt thereof is provided, the process including reacting a late intermediate compound which is 2-[1-[1-R-3-[2-(7 chloro quinolin-2-yl)vinyl [phenyl]-3-[2-methoxy carbonyl phenyl]propyl sulfonyl methyl]cyclo propyl]acetic acid or a salt thereof with methyl magnesium chloride or methyl magnesium bromide in an organic solvent. In one embodiment, the process includes reacting an earlier intermediate compound which is methyl 2-(3-R-(3-(2-(7-chloro 2-quinolinyl)-ethenyl)-3 hydroxy propyl)benzoate with methane sulfonyl chloride or toluene sulfonyl chloride to obtain a mesylated or tosylated derivative of the earlier intermediate compound; followed by a reaction of the mesylated or tosylated derivative with 1-mercapto methyl cyclopropane acetic acid in a polar solvent in a presence of a base to obtain the late intermediate compound.

摘要翻译： 提供了一种制备孟鲁司特或其盐的方法，该方法包括使2- [1- [1- [3- [2-（7-氯喹啉-2-基）乙烯基] [苯基 ] -3- [2-甲氧基羰基苯基]丙基磺酰基甲基]环丙基]乙酸或其盐与甲基氯化镁或甲基溴化镁在有机溶剂中反应。 在一个实施方案中，该方法包括使2-（3-R-（3-（2-（7-氯-2-喹啉基） - 乙烯基）-3-羟基丙基）苯甲酸甲酯与甲磺酰氯反应的较早中间体化合物或 甲磺酰氯，得到较早期中间体化合物的甲磺酰化或甲磺酰化衍生物;随后在极性溶剂中，在碱的存在下，使甲磺酰化或甲硅烷基化衍生物与1-巯基甲基环丙烷乙酸反应，得到后期中间体化合物 。