公开(公告)号：US11446280B2

公开(公告)日：2022-09-20

申请号：US16679313

申请日：2019-11-11

Applicant: Versitech Limited

Inventor： Yi Tsun Richard Kao ,  Peng Gao ,  Xuechen Li ,  Ming Liu

IPC: A61K31/40 ,  A61K31/496 ,  A61K31/47 ,  A61K31/454 ,  A61K31/4453 ,  A61K31/444 ,  A61K31/4406 ,  A61K31/4402 ,  A61K31/404 ,  A61K31/18 ,  A61K31/167 ,  A61K31/357 ,  A61P31/04 ,  C07D317/60 ,  C07D295/26

Abstract: Provided herein are compounds, derivatives thereof, and compositions including one or more of the compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): The present methods include administering to a subject an effective amount of one or more compounds of Formula (I). In one embodiment, the microbial infections are bacterial infections. More specifically, the bacterial infections are staphylococcal infections.

公开(公告)号：US11052078B2

公开(公告)日：2021-07-06

申请号：US16867540

申请日：2020-05-05

Applicant: Versitech Limited

Inventor： Yi Tsun Richard Kao ,  Peng Gao ,  Xuechen Li ,  Ming Liu

IPC: A61K31/4545 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/404 ,  A61K31/47 ,  A61P31/04 ,  A61K31/18 ,  A61K31/4458 ,  A61K31/4462 ,  A61K31/496 ,  A61K31/472

Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

公开(公告)号：US11040949B2

公开(公告)日：2021-06-22

申请号：US17006985

申请日：2020-08-31

Applicant: Versitech Limited

Inventor： Yi Tsun Richard Kao ,  Peng Gao ,  Xuechen Li ,  Ming Liu

IPC: C07D295/08 ,  A61K9/00 ,  C07D215/58 ,  C07D217/06 ,  A61P31/04

Abstract: Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives, and methods for prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (II): The present methods include administering to a subject an effective amount of one or more compounds of Formula (II). In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.

公开(公告)号：US10647746B2

公开(公告)日：2020-05-12

申请号：US15093950

申请日：2016-04-08

Applicant: Versitech Limited

Inventor： Xuechen Li

IPC: C07K7/54 ,  C07K7/08 ,  A61K38/00

Abstract: Described are design and generation of a set of novel cyclic lipopeptides as potential antibacterial agents. New daptomycin analogues are generated by chemical synthesis, which makes introduction of an unnatural amino acid and any modification into daptomycin possible.

公开(公告)号：US11667674B2

公开(公告)日：2023-06-06

申请号：US16310364

申请日：2017-03-24

Applicant: Versitech Limited

Inventor： Xuechen Li ,  Hoi Yee Chow

IPC: C07K7/08 ,  A61P31/04 ,  A61K38/00

CPC classification number: C07K7/08 ,  A61P31/04 ,  A61K38/00

Abstract: Cyclic lipopeptides having one or more modifications relative to daptomycin, and methods of making them are provided. The cyclic lipopeptides can be used as antibacterial agents. The daptomycin analogues are generated by chemical synthesis, which makes introduction of an unnatural amino acid and any modification into daptomycin possible. Pharmaceutical compositions and method of use thereof for the disclosed daptomycin analogues are also provided.

公开(公告)号：US20200010506A1

公开(公告)日：2020-01-09

申请号：US16310364

申请日：2017-03-24

Applicant: Versitech Limited

Inventor： Xuechen Li ,  Hoi Yee Chow

IPC: C07K7/08 ,  A61P31/04

Abstract: Cyclic lipopeptides having one or more modifications relative to daptomycin, and methods of making them are provided. The cyclic lipopeptides can be used as antibacterial agents. The daptomycin analogues are generated by chemical synthesis, which makes introduction of an unnatural amino acid and any modification into daptomycin possible. Pharmaceutical compositions and method of use thereof for the disclosed daptomycin analogues are also provided.