公开(公告)号：US20200283405A1

公开(公告)日：2020-09-10

申请号：US16702891

申请日：2019-12-04

申请人： Vertex Pharmaceuticals Incorporated

发明人： Timothy Alcacio ,  Minson Baek ,  Peter Grootenhuis ,  Sara Sabina Hadida Ruah ,  Robert M. Hughes ,  Ali Keshavarz-Shokri ,  Rachel McAuley-Aoki ,  Jason McCartney ,  Mark Thomas Miller ,  Fredrick Van Goor ,  Beili Zhang ,  Corey Anderson ,  Thomas Cleveland ,  Bryan A. Frieman ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Vito Melillo ,  Fabrice Jean Denis Pierre ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou ,  Alexander Russell Abela ,  Brett Bradley Busch ,  Prasuna Paraselli

IPC分类号： C07D401/14 ,  C07D471/14 ,  C07D498/14 ,  C07B59/00

摘要： Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

公开(公告)号：US10570115B2

公开(公告)日：2020-02-25

申请号：US15721390

申请日：2017-09-29

申请人： Vertex Pharmaceuticals Incorporated

发明人： Timothy Alcacio ,  Minson Baek ,  Peter Grootenhuis ,  Sara Sabina Hadida Ruah ,  Robert M. Hughes ,  Ali Keshavarz-Shokri ,  Rachel McAuley-Aoki ,  Jason McCartney ,  Mark Thomas Miller ,  Fredrick Van Goor ,  Beili Zhang ,  Corey Anderson ,  Thomas Cleveland ,  Bryan A. Frieman ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Vito Melillo ,  Fabrice Jean Denis Pierre ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou ,  Alexander Russell Abela ,  Brett Bradley Busch ,  Prasuna Paraselli ,  David Andrew Siesel

IPC分类号： C07D401/14 ,  A61K31/465 ,  A61K31/455 ,  A61K31/4155 ,  A61K31/4025 ,  C07D471/14 ,  C07D498/14 ,  C07B59/00

摘要： Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

公开(公告)号：US20180093969A1

公开(公告)日：2018-04-05

申请号：US15721390

申请日：2017-09-29

申请人： Vertex Pharmaceuticals Incorporated

发明人： Timothy Alcacio ,  Minson Baek ,  Peter Grootenhuis ,  Sara Sabina Hadida Ruah ,  Robert M. Hughes ,  Ali Keshavarz-Shokri ,  Rachel McAuley-Aoki ,  Jason McCartney ,  Mark Thomas Miller ,  Fredrick Van Goor ,  Beili Zhang ,  Corey Anderson ,  Thomas Cleveland ,  Bryan A. Frieman ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Vito Melillo ,  Fabrice Jean Denis Pierre ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou ,  Alexander Russell Abela ,  Brett Bradley Busch ,  Prasuna Paraselli ,  David Andrew Siesel

IPC分类号： C07D401/14 ,  C07B59/00

摘要： Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

公开(公告)号：US11186566B2

公开(公告)日：2021-11-30

申请号：US16702891

申请日：2019-12-04

申请人： Vertex Pharmaceuticals Incorporated

发明人： Timothy Alcacio ,  Minson Baek ,  Peter Grootenhuis ,  Sara Sabina Hadida Ruah ,  Robert M. Hughes ,  Ali Keshavarz-Shokri ,  Rachel McAuley-Aoki ,  Jason McCartney ,  Mark Thomas Miller ,  Fredrick Van Goor ,  Beili Zhang ,  Corey Anderson ,  Thomas Cleveland ,  Bryan A. Frieman ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Vito Melillo ,  Fabrice Jean Denis Pierre ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou ,  Alexander Russell Abela ,  Brett Bradley Busch ,  Prasuna Paraselli

IPC分类号： C07D401/14 ,  C07D471/14 ,  C07D498/14 ,  C07B59/00

摘要： Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

公开(公告)号：US20220306606A1

公开(公告)日：2022-09-29

申请号：US17505699

申请日：2021-10-20

申请人： Vertex Pharmaceuticals Incorporated

发明人： Timothy Alcacio ,  Minson Baek ,  Peter Grootenhuis ,  Sara Sabina Hadida Ruah ,  Robert M. Hughes ,  Ali Keshavarz-Shokri ,  Rachel McAuley-Aoki ,  Jason McCartney ,  Mark Thomas Miller ,  Fredrick Van Goor ,  Beili Zhang ,  Corey Anderson ,  Thomas Cleveland ,  Bryan A. Frieman ,  Haripada Khatuya ,  Pramod Virupax Joshi ,  Paul John Krenitsky ,  Vito Melillo ,  Fabrice Jean Denis Pierre ,  Andreas P. Termin ,  Johnny Uy ,  Jinglan Zhou ,  Alexander Russell Abela ,  Brett Bradley Busch ,  Prasuna Paraselli

IPC分类号： C07D401/14 ,  C07D471/14 ,  C07D498/14 ,  C07B59/00

摘要： Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.