公开(公告)号：US20190256516A1

公开(公告)日：2019-08-22

申请号：US16192134

申请日：2018-11-15

申请人： Vertex Pharmaceuticals Incorporated

发明人： Jean-Damien Charrier ,  Christopher John Davis ,  Damien Fraysse ,  Gorka Etxebarria I Jardi ,  Simon Pegg ,  Francoise Pierard ,  Joanne Pinder ,  John Studley ,  Carl Zwicker ,  Tapan Sanghvi ,  Michael Waldo ,  Ales Medek ,  David Matthew Shaw ,  Maninder Panesar ,  Yuegang Zhang ,  Naziha Alem

IPC分类号： C07D487/04 ,  C07B59/00 ,  C07C45/63 ,  C07C45/00

摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.

公开(公告)号：US10815239B2

公开(公告)日：2020-10-27

申请号：US16192134

申请日：2018-11-15

申请人： Vertex Pharmaceuticals Incorporated

发明人： Jean-Damien Charrier ,  Christopher John Davis ,  Damien Fraysse ,  Gorka Etxebarria I Jardi ,  Simon Pegg ,  Francoise Pierard ,  Joanne Pinder ,  John Studley ,  Carl Zwicker ,  Tapan Sanghvi ,  Michael Waldo ,  Ales Medek ,  David Matthew Shaw ,  Maninder Panesar ,  Yuegang Zhang ,  Naziha Alem

IPC分类号： C07D487/04 ,  A61K31/519 ,  C07B59/00 ,  C07C45/00 ,  C07C45/63

摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.

公开(公告)号：US20150158872A1

公开(公告)日：2015-06-11

申请号：US14561368

申请日：2014-12-05

申请人： Vertex Pharmaceuticals Incorporated

发明人： Jean-Damien Charrier ,  Christopher John Davis ,  Damien Fraysse ,  Gorka Etxebarria I Jardi ,  Simon Pegg ,  Francoise Pierard ,  Joanne Pinder ,  John Studley ,  Carl Zwicker ,  Tapan Sanghvi ,  Michael Waldo ,  Ales Medek ,  David Matthew Shaw ,  Maninder Panesar ,  Yuegang Zhang ,  Naziha Alem

IPC分类号： C07D487/04 ,  C07C45/63 ,  C07C45/00

CPC分类号： C07D487/04 ,  C07B59/002 ,  C07B2200/05 ,  C07B2200/13 ,  C07C45/00 ,  C07C45/63

摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.

摘要翻译： 本发明涉及可用作ATR蛋白激酶抑制剂的化合物。 本发明涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 和本发明化合物的固体形式。 本发明的化合物具有式I-A或I-B：其中变量如本文所定义。

公开(公告)号：US11485739B2

公开(公告)日：2022-11-01

申请号：US16994968

申请日：2020-08-17

申请人： Vertex Pharmaceuticals Incorporated

发明人： Jean-Damien Charrier ,  Christopher John Davis ,  Damien Fraysse ,  Gorka Etxebarria I Jardi ,  Simon Pegg ,  Francoise Pierard ,  Joanne Pinder ,  John Studley ,  Carl Zwicker ,  Tapan Sanghvi ,  Michael Waldo ,  Ales Medek ,  David Matthew Shaw ,  Maninder Panesar ,  Yuegang Zhang ,  Naziha Alem

IPC分类号： C07D487/04 ,  C07C45/00 ,  C07C45/63 ,  C07B59/00 ,  A61K31/519

摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.
The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.

公开(公告)号：US10160760B2

公开(公告)日：2018-12-25

申请号：US14561368

申请日：2014-12-05

申请人： Vertex Pharmaceuticals Incorporated

发明人： Jean-Damien Charrier ,  Christopher John Davis ,  Damien Fraysse ,  Gorka Etxebarria I Jardi ,  Simon Pegg ,  Francoise Pierard ,  Joanne Pinder ,  John Studley ,  Carl Zwicker ,  Tapan Sanghvi ,  Michael Waldo ,  Ales Medek ,  David Matthew Shaw ,  Maninder Panesar ,  Yuegang Zhang ,  Naziha Alem

IPC分类号： C07D487/04 ,  A61K31/519 ,  C07C45/00 ,  C07C45/63 ,  C07B59/00 ,  A61P35/00

摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.