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公开(公告)号：US09914747B2
公开(公告)日：2018-03-13
申请号：US15521957
申请日：2015-11-12
发明人： Jie Chen , Yan Chen , Nicholas A. Meanwell , Alicia Regueiro-Ren , Sing-Yuen Sit , Jacob Swidorski
CPC分类号： C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I and II: These compounds are useful for the treatment of HIV and AIDS.
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公开(公告)号：US11084845B2
公开(公告)日：2021-08-10
申请号：US16534208
申请日：2019-08-07
发明人： Jie Chen , Yan Chen , Ira B. Dicker , Richard A. Hartz , Nicholas A. Meanwell , Beata Nowicka-Sans , Alicia Regueiro-Ren , Sing-Yuen Sit , Ny Sin , Jacob Swidorski , Brian Lee Venables
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
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公开(公告)号：US09969767B2
公开(公告)日：2018-05-15
申请号：US15524298
申请日：2015-11-12
CPC分类号： C07J63/008
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I and II: These compounds are useful for the treatment of HIV and AIDS.
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公开(公告)号：US20230295220A1
公开(公告)日：2023-09-21
申请号：US18083037
申请日：2022-12-16
发明人： Jie CHEN , Yan Chen , Ira B. Dicker , Richard A. Hartz , Nicholas A. Meanwell , Beata Nowicka-Sans , Alicia Regueiro-ren , Sing-Yeun Sit , Ny Sin , Jacob Swidorski , Brian Lee Venables
CPC分类号： C07J53/002 , A61P31/18 , C07J63/008 , C12N9/506 , C12N2740/16222
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I:
These compounds are useful for the treatment of HIV and AIDS.-
公开(公告)号：US20210323997A1
公开(公告)日：2021-10-21
申请号：US17342941
申请日：2021-06-09
发明人： Jie CHEN , Yan Chen , Ira B. Dicker , Richard A. Hartz , Nicholas A. Meanwell , Beata Nowicka-Sans , Alicia Regueiro-Ren , Sing-Yuen Sit , Ny Sin , Jacob Swidorski , Brian Lee Venables
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
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公开(公告)号：US09920090B2
公开(公告)日：2018-03-20
申请号：US15313139
申请日：2015-06-17
发明人： Alicia Regueiro-Ren , Animesh Goswami , Zhiwei Guo , Thomas P. Tully , Jacob Swidorski , Zheng Liu , Nicholas A. Meanwell
CPC分类号： C07J63/008 , C07J71/001 , C07J71/0026
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivaties that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III: These compounds are useful for the treatment of HIV and AIDS.
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公开(公告)号：US10421774B2
公开(公告)日：2019-09-24
申请号：US16071925
申请日：2017-02-02
发明人： Jie Chen , Yan Chen , Ira B. Dicker , Richard A. Hartz , Nicholas A. Meanwell , Beata Nowicka-Sans , Alicia Regueiro-Ren , Sing-Yuen Sit , Ny Sin , Jacob Swidorski , Brian Lee Venables
摘要： Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
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