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1.发明申请STREPTOCOCCUS BACTERIOPHAGE LYSINS FOR DETECTION AND TREATMENT OF GRAM POSITIVE BACTERIA 有权STRATTOCOCCUS BACTERIOPHAGE LYSINS用于检测和治疗GRAM阳性细菌公开(公告)号：US20140072549A1
公开(公告)日：2014-03-13
申请号：US14112963
申请日：2012-04-20
IPC分类号： A61K38/47
CPC分类号： C12N9/2462 , A61K38/162 , A61K38/47 , A61K38/50 , A61K45/06 , C12Y302/01017
摘要： The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including Streptococcus and Staphylococcus, and related conditions. The invention provides compositions and methods incorporating and utilizing Streptococcus suis derived bacteriophage lysins, particularly PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of humans are provided.
摘要翻译： 本发明提供了可用于预防和治疗改善和治疗包括链球菌和葡萄球菌在内的革兰氏阳性菌及其相关条件的方法，组合物和制品。 本发明提供了组合物和方法，该组合物和方法并入并利用来自猪链球菌的噬菌体溶素，特别是PlySs2和/或PlySs1裂解酶及其变体，包括其截短。 提供了治疗人的方法。
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2.发明申请公开(公告)号：US20170298334A1
公开(公告)日：2017-10-19
申请号：US15492128
申请日：2017-04-20
摘要： The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including Streptococcus and Staphylococcus, and related conditions. The invention provides compositions and methods incorporating and utilizing Streptococcus suis derived bacteriophage lysins, particularly PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of humans are provided.
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3.发明授权Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria 有权链球菌噬菌体溶素用于检测和治疗革兰氏阳性菌公开(公告)号：US09034322B2
公开(公告)日：2015-05-19
申请号：US14112963
申请日：2012-04-20
CPC分类号： C12N9/2462 , A61K38/162 , A61K38/47 , A61K38/50 , A61K45/06 , C12Y302/01017
摘要： The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including Streptococcus and Staphylococcus, and related conditions. The invention provides compositions and methods incorporating and utilizing Streptococcus suis derived bacteriophage lysins, particularly PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of humans are provided.
摘要翻译： 本发明提供了可用于预防和治疗改善和治疗包括链球菌和葡萄球菌在内的革兰氏阳性菌及其相关条件的方法，组合物和制品。 本发明提供了组合物和方法，该组合物和方法并入并利用来自猪链球菌的噬菌体溶素，特别是PlySs2和/或PlySs1裂解酶及其变体，包括其截短。 提供了治疗人的方法。
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公开(公告)号：US09914915B2
公开(公告)日：2018-03-13
申请号：US14685696
申请日：2015-04-14
IPC分类号： A61K38/00 , A61K9/14 , A61K9/06 , C12N9/14 , C12N9/36 , A61K38/16 , A61K38/50 , A61K38/47 , A61K45/06
CPC分类号： C12N9/2462 , A61K38/162 , A61K38/47 , A61K38/50 , A61K45/06 , C12Y302/01017
摘要： The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including Streptococcus and Staphylococcus, and related conditions. The invention provides compositions and methods incorporating and utilizing Streptococcus suis derived bacteriophage lysins, particularly PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of humans are provided.
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5.发明申请STREPTOCOCCUS BACTERIOPHAGE LYSINS FOR DETECTION AND TREATMENT OF GRAM POSITIVE BACTERIA 有权STRATTOCOCCUS BACTERIOPHAGE LYSINS用于检测和治疗GRAM阳性细菌公开(公告)号：US20150267185A1
公开(公告)日：2015-09-24
申请号：US14685696
申请日：2015-04-14
CPC分类号： C12N9/2462 , A61K38/162 , A61K38/47 , A61K38/50 , A61K45/06 , C12Y302/01017
摘要： The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including Streptococcus and Staphylococcus, and related conditions. The invention provides compositions and methods incorporating and utilizing Streptococcus suis derived bacteriophage lysins, particularly PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of humans are provided.
摘要翻译： 本发明提供了可用于预防和治疗改善和治疗包括链球菌和葡萄球菌在内的革兰氏阳性菌及其相关条件的方法，组合物和制品。 本发明提供了组合物和方法，该组合物和方法并入并利用来自猪链球菌的噬菌体溶素，特别是PlySs2和/或PlySs1裂解酶及其变体，包括其截短。 提供了治疗人的方法。
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6.发明申请STREPTOCOCCUS BACTERIOPHAGE LYSINS FOR TREATMENT OF GRAM POSITIVE BACTERIA IN COMPANION ANIMALS AND LIVESTOCK 审中-公开用于治疗公鸡动物和畜牧业中的积极细菌的细菌性细菌性淋巴细胞公开(公告)号：US20140179594A1
公开(公告)日：2014-06-26
申请号：US14112975
申请日：2012-04-20
申请人： Vincent A. Fischetti , Jonathan Schmitz , Daniel Gilmer , Jacob Anthony Wagenaar , Jan Arend Stegeman
发明人： Vincent A. Fischetti , Jonathan Schmitz , Daniel Gilmer , Jacob Anthony Wagenaar , Jan Arend Stegeman
IPC分类号： A61K38/16
CPC分类号： A61K38/164 , A61K38/47 , C12Y302/01017
摘要： The present invention provides methods for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria in companion animals and livestock, including Streptococcus and Staphylococcus bacterial strains, including pathogenic and antibiotic-resistant bacteria, and related conditions. The methods of the invention utilize PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of companion animals and livestock are provided.
摘要翻译： 本发明提供了包括链球菌和葡萄球菌细菌菌株在内的伴侣动物和牲畜中革兰氏阳性菌的预防和治疗改善和治疗方法，包括病原菌和抗生素抗性细菌以及相关条件。 本发明的方法利用PlySs2和/或PlySs1裂解酶及其变体，包括其截短。 提供了处理伴侣动物和牲畜的方法。
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