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公开(公告)号:US08946269B2
公开(公告)日:2015-02-03
申请号:US13223023
申请日:2011-08-31
申请人: Vincent R. Capodanno , Liam Corcoran , Michael McNevin , Itzia Zoraida Arroyo , Robert M. Wenslow , Richard G. Ball , Eric L. Margelefsky , Timothy K. Maher , Anjali Pandey
发明人: Vincent R. Capodanno , Liam Corcoran , Michael McNevin , Itzia Zoraida Arroyo , Robert M. Wenslow , Richard G. Ball , Eric L. Margelefsky , Timothy K. Maher , Anjali Pandey
IPC分类号: A61K31/44 , C07D213/75
CPC分类号: A61K31/44 , C07D213/75
摘要: Provided herein are crystalline forms of a maleate salt of betrixaban, compositions and methods of preparation or use thereof.
摘要翻译: 本文提供的是betrixaban的马来酸盐的结晶形式,组合物及其制备方法或用途。
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2.METHODS AND FORMULATIONS OF TREATING THROMBOSIS WITH BETRIXABAN AND A P-GLYCOPROTEIN INHIBITOR 审中-公开
标题翻译: 用BETRIXABAN和P-GLYCOPROTEIN抑制剂治疗血栓形成的方法和制剂公开(公告)号:US20120095019A1
公开(公告)日:2012-04-19
申请号:US13223038
申请日:2011-08-31
申请人: Uma Sinha , George A. Mansoor , Anne Hermanowski Vosatka , Vincent R. Capodanno , Robert M. Wenslow , Richard G. Ball , Eric L. Margelefsky , Timothy K. Maher , Itzia Zoraida Arroyo , Brett Lauring , Liam Corcoran , William Denney , Michael McNevin , Anjali Pandey
发明人: Uma Sinha , George A. Mansoor , Anne Hermanowski Vosatka , Vincent R. Capodanno , Robert M. Wenslow , Richard G. Ball , Eric L. Margelefsky , Timothy K. Maher , Itzia Zoraida Arroyo , Brett Lauring , Liam Corcoran , William Denney , Michael McNevin , Anjali Pandey
IPC分类号: A61K31/44 , A61P7/02 , A61K31/496
CPC分类号: A61K31/277 , A61K31/343 , A61K31/435 , A61K31/44 , A61K31/496 , A61K45/06 , A61K2300/00
摘要: This invention is directed to methods of inhibiting coagulation or treating thrombosis using a factor Xa inhibitor and a P-glycoprotein (Pgp) inhibitor. The invention is also directed to formulations used in the methods.
摘要翻译: 本发明涉及使用因子Xa抑制剂和P-糖蛋白(Pgp)抑制剂来抑制凝血或治疗血栓形成的方法。 本发明还涉及用于该方法的制剂。
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公开(公告)号:US20120071519A1
公开(公告)日:2012-03-22
申请号:US13223023
申请日:2011-08-31
申请人: Vincent R. Capodanno , Liam Corcoran , Michael McNevin , Itzia Zoraida Arroyo , Robert M. Wenslow , Richard G. Ball , Eric L. Margelefsky , Timothy K. Maher , Anjali Pandey
发明人: Vincent R. Capodanno , Liam Corcoran , Michael McNevin , Itzia Zoraida Arroyo , Robert M. Wenslow , Richard G. Ball , Eric L. Margelefsky , Timothy K. Maher , Anjali Pandey
IPC分类号: A61K31/44 , A61P7/02 , A61P9/10 , C07D213/75
CPC分类号: A61K31/44 , C07D213/75
摘要: Provided herein are crystalline forms of a maleate salt of betrixaban, compositions and methods of preparation or use thereof.
摘要翻译: 本文提供的是betrixaban的马来酸盐的结晶形式,组合物及其制备方法或用途。
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