中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

6 records (took 0.014 seconds)

    Induction of Tumor Hypoxia for Cancer Therapy
    1.
    发明申请
    Induction of Tumor Hypoxia for Cancer Therapy 有权
    诱导肿瘤治疗的肿瘤缺氧

    公开(公告)号：US20140065139A1

    公开(公告)日：2014-03-06

    申请号：US14043661

    申请日：2013-10-01

    Applicant: Virginia Commonwealth University

    Inventor： Ruey-min Lee ,  Peck-sun Lin

    IPC: A61K31/53 ,  A61K39/395 ,  A61K31/135

    CPC classification number: A61K31/53 ,  A61K9/0019 ,  A61K31/135 ,  A61K31/167 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/46 ,  C07K16/22 ,  C07K2317/24 ,  A61K2300/00

    Abstract: Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.

    Abstract translation: 提供了用于增强缺氧活化的生物还原剂杀死实体瘤内肿瘤细胞的能力的方法和组合物。 在肿瘤内，或含有肿瘤的区域内产生缺氧的局部区域，导致局部区域内缺氧激活的生物还原剂（如替拉扎明）的活化增强。 活化的缺氧活化的生物还原剂通过催化肿瘤细胞内的DNA断裂来杀死缺氧区域的肿瘤细胞。 因为活性是局部化的，所以通常作为全身给药生物还原剂而发生的副作用减少了。

    Induction of tumor hypoxia for cancer therapy
    2.
    发明授权
    Induction of tumor hypoxia for cancer therapy 有权

    公开(公告)号：US10426779B2

    公开(公告)日：2019-10-01

    申请号：US15480250

    申请日：2017-04-05

    Applicant: Virginia Commonwealth University

    Inventor： Ruey-min Lee ,  Peck-sun Lin

    IPC: A61K31/53 ,  A61K31/167 ,  A61K39/395 ,  C07K16/22 ,  A61K31/135 ,  A61K9/00 ,  A61K45/06 ,  A61K47/46

    Abstract: Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by to catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.

    Induction of tumor hypoxia for cancer therapy
    4.
    发明授权
    Induction of tumor hypoxia for cancer therapy 有权

    公开(公告)号：US10159676B2

    公开(公告)日：2018-12-25

    申请号：US15480242

    申请日：2017-04-05

    Applicant: Virginia Commonwealth University

    Inventor： Ruey-min Lee ,  Peck-sun Lin

    IPC: A61K31/53 ,  A61K31/167 ,  A61K39/395 ,  C07K16/22 ,  A61K31/135 ,  A61K9/00 ,  A61K45/06 ,  A61K47/46

    Abstract: Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g. tirapazamine) within the local region. The activated hypoxia-activated bioreductive agents kill tumor cells in the hypoxic region by catalyzing DNA stand breakage within the tumor cells. Because the activity is localized, side effects that typically occur as a result of systemic administration of bioreductive agents are reduced.

Patent Agency Ranking