公开(公告)号：US20190169225A1

公开(公告)日：2019-06-06

申请号：US16154007

申请日：2018-10-08

Applicant: Virginia Commonwealth University

Inventor： Shunlin Ren ,  William M. Pandak

IPC: C07J31/00 ,  C07J9/00

Abstract: The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.

公开(公告)号：US20180346509A9

公开(公告)日：2018-12-06

申请号：US15042244

申请日：2016-02-12

Applicant: Virginia Commonwealth University

Inventor： Shunlin Ren ,  William M. Pandak

IPC: C07J31/00

CPC classification number: C07J31/006 ,  C07J9/00

Abstract: The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.

公开(公告)号：US09321802B2

公开(公告)日：2016-04-26

申请号：US13766839

申请日：2013-02-14

Applicant: Virginia Commonwealth University

Inventor： Shunlin Ren ,  William M. Pandak

IPC: A61K31/575 ,  C07J31/00 ,  C07J9/00

CPC classification number: C07J31/006 ,  C07J9/00

Abstract: The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.

公开(公告)号：US20160264615A1

公开(公告)日：2016-09-15

申请号：US15042244

申请日：2016-02-12

Applicant: Virginia Commonwealth University

Inventor： Shunlin Ren ,  William M. Pandak

IPC: C07J31/00

CPC classification number: C07J31/006 ,  C07J9/00

Abstract: The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.

Abstract translation: 提供了降低脂质生物合成并增加胆固醇分泌和降解的核胆固醇代谢产物硫酸氢化甾醇5胆甾醇-3β，25-二醇3-硫酸酯，作为降低细胞内和血清胆固醇和/或甘油三酯的药物，并防止 或治疗与这种炎症相关的脂质积聚相关的炎症和病症。 还提供涉及使用该硫酸化氧固醇来治疗与高胆固醇和/或高甘油三酸酯和/或炎症相关的病症（例如高胆固醇血症，高甘油三酯血症，非酒精性脂肪性肝病，动脉粥样硬化等）的方法。

公开(公告)号：US11384115B2

公开(公告)日：2022-07-12

申请号：US17060886

申请日：2020-10-01

Applicant: Virginia Commonwealth University

Inventor： Shunlin Ren ,  William M. Pandak

IPC: C07J31/00 ,  C07J9/00 ,  A61K31/575

Abstract: The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.

公开(公告)号：US20210147469A1

公开(公告)日：2021-05-20

申请号：US17060886

申请日：2020-10-01

Applicant: Virginia Commonwealth University

Inventor： Shunlin Ren ,  William M. Pandak

IPC: C07J31/00 ,  C07J9/00 ,  A61K31/575

Abstract: The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.

公开(公告)号：US10144759B2

公开(公告)日：2018-12-04

申请号：US15042244

申请日：2016-02-12

Applicant: Virginia Commonwealth University

Inventor： Shunlin Ren ,  William M. Pandak

IPC: A61K31/575 ,  C07J9/00 ,  C07J31/00

CPC classification number: C07J31/006 ,  C07J9/00

Abstract: The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.

公开(公告)号：US20130143854A1

公开(公告)日：2013-06-06

申请号：US13766839

申请日：2013-02-14

Applicant: Virginia Commonwealth University

Inventor： Shunlin Ren ,  William M. Pandak

IPC: C07J31/00

CPC classification number: C07J31/006 ,  C07J9/00

Abstract: The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and/or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and/or high triglycerides and/or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.

Abstract translation: 提供了降低脂质生物合成并增加胆固醇分泌和降解的核胆固醇代谢产物硫酸化氧胆固醇5-胆固醇-3β，25-二醇3-硫酸盐，作为降低细胞内和血清胆固醇和/或甘油三酯的药物，并防止 或治疗与这种炎症相关的脂质积聚相关的炎症和病症。 还提供涉及使用该硫酸化氧固醇来治疗与高胆固醇和/或高甘油三酸酯和/或炎症相关的病症（例如高胆固醇血症，高甘油三酯血症，非酒精性脂肪性肝病，动脉粥样硬化等）的方法。