公开(公告)号：US20170360326A1

公开(公告)日：2017-12-21

申请号：US15536333

申请日：2015-12-15

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： RAFAEL V. DAVALOS ,  MOHAMMAD BONAKDAR ,  EDUARDO L. LATOUCHE ,  ROOP L. MAHAJAN ,  JOHN L. ROBERTSON ,  CHRISTOPHER B. ARENA ,  MICHAEL B. SANO

IPC: A61B5/053 ,  G01N33/543 ,  A61B5/01

Abstract: Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy. Provided herein are embodiments of an electrical conductivity sensor having an impedance sensor, where the impedance sensor can be configured to measure a low-frequency and a high-frequency impedance and a substrate, where the impedance sensor is coupled to the substrate. The substrate can be flexible. In embodiments, the impedance sensor can contain two or more electrical conductors. The electrical conductors can be in a bipolar configuration. The electrical conductors can be in a tetrapolar configuration. In embodiments, the electrical conductivity sensor can have two impedance sensors that can be coupled to the substrate such that they are orthogonal to each other.

公开(公告)号：US20200046967A1

公开(公告)日：2020-02-13

申请号：US16340106

申请日：2017-10-06

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： JILL W. IVEY ,  EDUARDO L. LATOUCHE ,  SCOTT S. VERBRIDGE ,  RAFAEL V. DAVALOS ,  GLENN J. LESSER ,  WALDEMAR DEBINSKI

IPC: A61N1/32 ,  A61N1/05 ,  A61N1/06 ,  A61K38/19

Abstract: Described herein are methods of electroporation that can include the steps of contacting a cell that is responsive to an EphA2 receptor ligand with an amount of an EphA2 receptor ligand and applying high-frequency irreversible electroporation to the cell. Also described herein are methods of treating cancer in a subject in need thereof, wherein the methods can include the steps of administering an amount of an EphA2 receptor ligand and applying high-frequency irreversible electroporation to a location on or within the subject.