公开(公告)号：US06716968B2

公开(公告)日：2004-04-06

申请号：US09915306

申请日：2001-07-27

申请人： Viveka Björklund ,  Bertil Björklund ,  Peter Björklund ,  Marius Nap ,  Frans C. S. Ramaekers ,  Bert Schutte

发明人： Viveka Björklund ,  Bertil Björklund ,  Peter Björklund ,  Marius Nap ,  Frans C. S. Ramaekers ,  Bert Schutte

IPC分类号： C07K1618

CPC分类号： C07K5/1021 ,  A61K38/00 ,  C07K14/4741 ,  C07K14/4747 ,  C07K16/18

摘要： Apoptosis-related antigenic compounds comprising an exposed antigenic site having the amino acid sequence SEQ ID NO: 1: Glu Asp Phe Asn Leu Gly Asp Ala Leu Asp 1               5                    10 or a functionally equivalent sequence comprising at least the sequence Ala Leu Asp are disclosed. Further, several applications and uses based on such compounds are included, such as use of the compounds in medicaments, nucleic acid sequences encoding the amino-acid sequence of such a peptide compound or protein fragment comprising the C-terminal amino acid sequence Ala Leu Asp, anti-sense nucleic acid sequence, vector comprising such a nucleic acid sequence, antibody or antigen-binding peptide recognizing such an antigenic compound and use thereof in a medicament, agents regulating the liberation of protein fragments comprising the amino-acid sequence SEQ ID NO: 1 or functionally equivalent sequences comprising the C-terminal amino acid sequence Ala Leu Asp, a method of determining the occurrence of cell apoptosis in a sample of biological material, especially in the diagnosis of degenerative diseases and cancer, or monitoring of the effect of therapy, a method of treating diseases with involvement of apoptosis, such as cancer and degenerative diseases, a method of creating cancer cells, and as carrier for prophylactic, therapeutic or diagnostic use.

摘要翻译： 公开了包含具有氨基酸序列的暴露的抗原位点或至少包含序列Ala Leu Asp的功能等同序列的凋亡相关抗原化合物。 此外，包括基于这些化合物的几种应用和用途，例如在药物中使用化合物，编码这种肽化合物的氨基酸序列的核酸序列或包含C-末端氨基酸序列Ala Leu Asp的蛋白质片段 ，反义核酸序列，包含这种核酸序列的载体，识别这种抗原性化合物的抗体或抗原结合肽及其在药物中的用途，调节释放包含氨基酸序列SEQ ID NO ：1或包含C-末端氨基酸序列Ala Leu Asp的功能等同序列，确定生物材料样品中细胞凋亡发生的方法，特别是在退行性疾病和癌症的诊断中，或监测其作用 治疗，涉及凋亡的疾病如癌症和退行性疾病的方法，一种产生癌症的方法 细胞，以及作为预防，治疗或诊断用途的载体。

公开(公告)号：US06706488B2

公开(公告)日：2004-03-16

申请号：US09915374

申请日：2001-07-27

申请人： Viveka Björklund ,  Bertil Björklund ,  Peter Björklund ,  Marius Nap ,  Frans C. S. Ramaekers ,  Bert Schutte

发明人： Viveka Björklund ,  Bertil Björklund ,  Peter Björklund ,  Marius Nap ,  Frans C. S. Ramaekers ,  Bert Schutte

IPC分类号： G01N3353

CPC分类号： C07K5/1021 ,  A61K38/00 ,  C07K14/4741 ,  C07K14/4747 ,  C07K16/18

摘要： Apoptosis-related antigenic compounds comprising an exposed antigenic site having the amino acid sequence SEQ ID NO: 1: Glu Asp Phe Asn Leu Gly Asp Ala Leu Asp 1               5                    10 or a functionally equivalent sequence comprising at least the sequence Ala Leu Asp are disclosed. Further, several applications and uses based on such compounds are included, such as use of the compounds in medicaments, nucleic acid sequences encoding the amino-acid sequence of such a peptide compound or protein fragment comprising the C-terminal amino acid sequence Ala Leu Asp, anti-sense nucleic acid sequence, vector comprising such a nucleic acid sequence, antibody or antigen-binding peptide recognizing such an antigenic compound and use thereof in a medicament, agents regulating the liberation of protein fragments comprising the amino-acid sequence SEQ ID NO: 1 or functionally equivalent sequences comprising the C-terminal amino acid sequence Ala Leu Asp, a method of determining the occurrence of cell apoptosis in a sample of biological material, especially in the diagnosis of degenerative diseases and cancer, or monitoring of the effect of therapy, a method of treating diseases with involvement of apoptosis, such as cancer and degenerative diseases, a method of creating cancer cells, and as carrier for prophylactic, therapeutic or diagnostic use.

公开(公告)号：US06296850B1

公开(公告)日：2001-10-02

申请号：US09162366

申请日：1998-09-29

申请人： Viveka Björklund ,  Bertil Björklund ,  Peter Björklund ,  Marius Nap ,  Frans C. S. Ramaekers ,  Bert Schutte

发明人： Viveka Björklund ,  Bertil Björklund ,  Peter Björklund ,  Marius Nap ,  Frans C. S. Ramaekers ,  Bert Schutte

IPC分类号： A61K3804

CPC分类号： C07K5/1021 ,  A61K38/00 ,  C07K14/4741 ,  C07K14/4747 ,  C07K16/18

摘要： Apoptosis-related antigenic compounds comprising an exposed antigenic site having the amino acid sequence SEQ ID NO: 1:   Glu Asp Phe Asn Leu Gly Asp Ala Leu Asp   1               5                    10 or a functionally equivalent sequence comprising at least the sequence Ala Leu Asp are disclosed. Further, several applications and uses based on such compounds are included, such as use of the compounds in medicaments, nucleic acid sequences encoding the amino-acid sequence of such a peptide compound or protein fragment comprising the C-terminal amino acid sequence Ala Leu Asp, anti-sense nucleic acid sequence, vector comprising such a nucleic acid sequence, antibody or antigen-binding peptide recognizing such an antigenic compound and use thereof in a medicament, agents regulating the liberation of protein fragments comprising the amino-acid sequence SEQ ID NO: 1 or functionally equivalent sequences comprising the C-terminal amino acid sequence Ala Leu Asp, a method of determining the occurrence of cell apoptosis in a sample of biological material, especially in the diagnosis of degenerative diseases and cancer, or monitoring of the effect of therapy, a method of treating diseases with involvement of apoptosis, such as cancer and degenerative diseases, a method of creating cancer cells, and as carrier for prophylactic, therapeutic or diagnostic use.

摘要翻译： 公开了包含具有氨基酸序列的暴露的抗原位点或至少包含序列Ala Leu Asp的功能等同序列的凋亡相关抗原化合物。 此外，包括基于这些化合物的几种应用和用途，例如在药物中使用化合物，编码这种肽化合物的氨基酸序列的核酸序列或包含C-末端氨基酸序列Ala Leu Asp的蛋白质片段 ，反义核酸序列，包含这种核酸序列的载体，识别这种抗原性化合物的抗体或抗原结合肽及其在药物中的用途，调节释放包含氨基酸序列SEQ ID NO ：1或包含C-末端氨基酸序列Ala Leu Asp的功能等同序列，确定生物材料样品中细胞凋亡发生的方法，特别是在退行性疾病和癌症的诊断中，或监测其作用 治疗，涉及凋亡的疾病如癌症和退行性疾病的方法，一种产生癌症的方法 细胞，以及作为预防，治疗或诊断用途的载体。