-
1.
公开(公告)号:US08637465B2
公开(公告)日:2014-01-28
申请号:US13322307
申请日:2009-05-27
申请人: Vladimir Berezin , Elisabeth Bock , Artur Kochoyan
发明人: Vladimir Berezin , Elisabeth Bock , Artur Kochoyan
IPC分类号: A61K38/17
CPC分类号: C07K16/42 , A61K38/179 , C07K2317/70
摘要: The present invention relates to the use of peptides that are capable of binding to, and modulating the activity of NCAM. The peptides are peptide fragments of FGFRs. They are derived from two distinct binding sites for binding of the immunoglobulin-like module 2 of FGFR to NCAM F3 modules 1-2. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein NCAM and/or FGFRs play a prominent role.
摘要翻译: 本发明涉及能够结合并调节NCAM活性的肽的用途。 肽是FGFR的肽片段。 它们衍生自用于结合FGFR的免疫球蛋白样模块2与NCAM F3模块1-2的两个不同的结合位点。 本发明还涉及所述肽在生产用于治疗不同病理状况的药物中的用途,其中NCAM和/或FGFRs起着重要作用。
-
2.
公开(公告)号:US20120141451A1
公开(公告)日:2012-06-07
申请号:US13322307
申请日:2009-05-27
申请人: Vladimir Berezin , Elisabeth Bock , Artur Kochoyan
发明人: Vladimir Berezin , Elisabeth Bock , Artur Kochoyan
IPC分类号: A61K38/45 , C07K16/40 , A61P25/18 , A61P25/16 , A61P9/00 , A61P25/00 , A61P21/00 , A61P13/12 , A61P25/28 , A61P17/02 , A61P35/00 , C12N9/12 , A61P25/24
CPC分类号: C07K16/42 , A61K38/179 , C07K2317/70
摘要: The present invention relates to the use of peptides that are capable of binding to, and modulating the activity of NCAM. The peptides are peptide fragments of FGFRs. They are derived from two distinct binding sites for binding of the immunoglobulin-like module 2 of FGFR to NCAM F3 modules 1-2. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein NCAM and/or FGFRs play a prominent role.
摘要翻译: 本发明涉及能够结合并调节NCAM活性的肽的用途。 肽是FGFR的肽片段。 它们衍生自用于结合FGFR的免疫球蛋白样模块2与NCAM F3模块1-2的两个不同的结合位点。 本发明还涉及所述肽在生产用于治疗不同病理状况的药物中的用途,其中NCAM和/或FGFRs起着重要作用。
-