专利检索 ap:("Vladimir R. Muzykantov" OR "Juan Carlos Murciano" OR "D. Neil Granger") AND inv:"D. Neil Granger" 第 1 页

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发明授权
Targeting and prolonging association of drugs to the luminal surface of the pulmonary vascular endothelial cells using antibodies that bind to ICAM-1 有权
标题翻译：使用结合ICAM-1的抗体靶向和延长药物与肺血管内皮细胞的腔表面的关联

公开(公告)号：US07674466B2

公开(公告)日：2010-03-09

申请号：US11234594

申请日：2005-09-23

申请人： Vladimir R. Muzykantov , Juan Carlos Murciano , D. Neil Granger

发明人： Vladimir R. Muzykantov , Juan Carlos Murciano , D. Neil Granger

IPC分类号： A61K39/00

CPC分类号： A61K47/6849

摘要： Methods for targeting and prolonging association of a selected drug to the luminal surface of pulmonary vascular endothelium of an animal are provided wherein a selected drug is administered to an animal in combination with a non-internalizable ICAM-1 antibody which binds to an antigen on the luminal surface of the pulmonary vasculature. This method is particularly useful in dissolution of fibrin clots or prevention of the intravascular coagulation in the pulmonary vasculature.

摘要翻译： 提供了将选择的药物与动物的肺血管内皮的腔表面的靶向和延长关联的方法，其中将选择的药物与不可内在化的ICAM-1抗体组合给予动物，所述非ICAM-1抗体与肺血管的腔表面。该方法在溶解纤维蛋白凝块或预防肺血管中的血管内凝血时特别有用。