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    Stabilized lithium acetylide and reactions therewith
    1.
    发明授权
    Stabilized lithium acetylide and reactions therewith 失效
    稳定的乙炔化锂及其反应

    公开(公告)号：US5068368A

    公开(公告)日：1991-11-26

    申请号：US521743

    申请日：1990-05-10

    申请人： W. Novis Smith ,  Christopher Louer

    发明人： W. Novis Smith ,  Christopher Louer

    IPC分类号： C07C29/42 ,  C07C33/042 ,  C07J7/00

    CPC分类号： C07C33/042 ,  C07C29/42 ,  C07J7/002

    摘要： A process for the preparation of ethynyl carbinols of the formula: ##STR1## wherein R" is hydrogen, a substituted or unsubstituted aliphatic or aromatic hydrocarbon, R'" is a substituted or unsubstituted aliphatic or aromatic hydrocarbon or R" and R'" together to the carbon atom to which they are joined represent a steroid, which comprises the steps ofA. reacting in a solvent system comprising an aromatic hydrocarbon, at least one lithium alkylamide selected from the group consisting of: ##STR2## wherein R is a hydrogen or lower alkyl, R' is hydrogen, lower alkyl, a substituted or unsubstituted aliphatic, alicyclic or aromatic hydrocarbon, x is an integer of 2 to 8, y and z are each 0 to 1, with acetylene to form a monolithium acetylideB. reacting in a solvent system comprising an aromatic hydrocarbon, the monolithium acetylene from Part A with a ketone of the formula R"R'"C.dbd.O, wherein R" and R'" are as hereinbefore defined, and thenC. hydrolysing the reaction product of Part B to form the corresponding ethynyl carbinol compound.

    摘要翻译： 一种制备下式的乙炔基甲醇的方法：其中R“是氢，取代或未取代的脂族或芳族烃，R”'是取代或未取代的脂族或芳族烃或R“和R “与它们连接的碳原子一起代表一种类固醇，其包括以下步骤：A.在包含芳族烃的溶剂体系中反应，至少一种选自以下的烷基胺化锂： 其中R为氢或低级烷基，R'为氢，低级烷基，取代或未取代的脂族，脂环族或芳族烃，x为2至8的整数，y和z各自为0至1，与乙炔 以形成单乙炔化物B.在包含芳族烃，来自A部分的单锂乙炔与式R''R''C = O的酮的溶剂体系中反应，其中R“和R”'为 如上所述，然后C.水解反应产物 的B部分形成相应的乙炔基甲醇化合物。