公开(公告)号：US20220098585A1

公开(公告)日：2022-03-31

申请号：US17426511

申请日：2020-01-30

Applicant: WAVE LIFE SCIENCES LTD.

Inventor： Jeffrey Matthew Brown ,  Shaunna Syu-Mei Berkovitch ,  Naoki Iwamoto ,  Chandra Vargeese ,  Kidist M. Aklilu ,  Maria David Frank-Kamenetsky ,  Duncan Parley Brown

IPC: C12N15/113

Abstract: Among other things, the present disclosure provides oligonucleotides, compositions, and methods for preventing and/or treating various conditions, disorders or diseases. In some embodiments, provided oligonucleotides comprise nucleobase modifications, sugar modifications, internucleotidic linkage modifications and/or patterns thereof, and have improved properties, activities and/or selectivities. In some embodiments, the present disclosure provides oligonucleotides, compositions and methods for HTT-related conditions, disorders or diseases, such as Huntington's disease.