公开(公告)号：US20250154190A1

公开(公告)日：2025-05-15

申请号：US18836993

申请日：2023-02-13

Applicant: WAVE LIFE SCIENCES LTD.

Inventor： Pachamuthu Kandasamy ,  Subramanian Marappan ,  Mamoru Shimizu ,  Chandra Vargeese ,  Jayakanthan Kumarasamy ,  Ik-Hyeon Paik ,  Marissa Sauter ,  Arindom Chatterjee

IPC: C07H19/067 ,  C07D207/08 ,  C07D207/09 ,  C07H19/16 ,  G01N33/53

Abstract: Among other things, the present disclosure provides technologies for stereoselective preparation chiral compounds. In some embodiments, prepared chiral compounds are useful for chirally controlled preparation of oligonucleotides. In some embodiments, such oligonucleotides target transcripts associate with various conditions, disorders or diseases.