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公开(公告)号：US20230398265A1
公开(公告)日：2023-12-14
申请号：US18252416
申请日：2021-11-09
发明人： Zhiqiang CAO , Ershuai ZHANG
CPC分类号： A61L31/06 , A61K9/0024 , A61L2400/12
摘要： The present disclosure provides compositions and methods for inhibition of tissue adhesion. According to specific aspects, implantable anti-adhesion zwitterionic compositions which include: an aqueous liquid; and a zwitterionic polymer are disclosed, wherein the zwitterionic polymer is, consists essentially of, or includes, poly(3-((3-acrylamidopropyl)dimethylammonio)propanoate) (PCBAA). According to specific aspects, implantable anti-adhesion zwitterionic compositions are provided which include nanoparticles and/or microparticles of zwitterionic hydrogel, wherein the zwitterionic hydrogel is, consists essentially of, or includes, PCBAA. Methods of inhibiting tissue adhesion in a subject in need thereof are provided according to aspects of the present disclosure which include administering an implantable anti-adhesion zwitterionic composition to a tissue surface exposed by surgery.
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